Home Categories Biochemical Engineering 5-Bromo-N-(4,5-Dihydro-1H-Imidazol-2-yl)-6-QuinoxalinamineTartrate
M0036835

5-Bromo-N-(4,5-Dihydro-1H-Imidazol-2-yl)-6-QuinoxalinamineTartrate , ≥99% , 70359-46-5

Synonym(s):
Brimonidine tartrate

CAS NO.:70359-46-5

Empirical Formula: C15H16BrN5O6

Molecular Weight: 442.22

MDL number: MFCD07773072

EINECS: 629-848-5

Pack Size Price Stock Quantity
50mg RMB249.60 In Stock
250mg RMB959.20 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: 207-208°C (dec.)
storage temp.  Inert atmosphere,Store in freezer, under -20°C
solubility  DMSO: 1 mg/ml; PBS (pH 7.2): 3 mg/ml
form  Solid
color  White to off-white
InChIKey QZHBYNSSDLTCRG-WUUYCOTASA-N
CAS DataBase Reference 70359-46-5(CAS DataBase Reference)

Description and Uses

Brimonidine is an agonist of α2-adrenergic receptors (α2-ARs; Kis = 2.7, 52, and 44 nM for α2A, α2B, and α2C-ARs, respectively, in CHO cells). It is selective for α2-ARs over α1-ARs (Ki = 1,800 nM in human brain). Brimonidine lowers intraocular pressure in DBA/2J mice, a model of glaucoma, to control levels when applied topically to the eye as a 0.1% solution. It also inhibits glutamate release, prevents upregulation of NMDA receptors containing NR1 and NR2A subunits, and protects rat retinal ganglion cells against glutamate excitotoxicity in a rat model of retinal ischemia when administered at a dose of 1 mg/kg per day. Formulations containing brimonidine have been used in the treatment of open-angle glaucoma and ocular hypertension.

It is an α2 receptor agonist. It is a drug used to treat glaucoma.

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P310-P302+P352-P305+P351+P338
RIDADR  UN 2811 6.1 / PGIII
HS Code  29332900

RELATED PRODUCTS