Brimonidine , >98.0%(HPLC) , 59803-98-4

Synonym(s):
5-Bromo-N-(2-imidazolin-2-yl)-6-quinoxalinamine;5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine;Brimonidine

CAS NO.：59803-98-4

Empirical Formula: C11H10BrN5

Molecular Weight: 292.13

MDL number: MFCD00153878

EINECS: 000-000-0

PRODUCT Properties

• Melting point: 207.5 °C
• Boiling point: 432.6±55.0 °C(Predicted)
• Density: 1.82±0.1 g/cm3(Predicted)
• storage temp.: Keep in dark place,Sealed in dry,2-8°C
• solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8 mg/mL
• form: powder to crystal
• pka: 7.69±0.10(Predicted)
• color: Light yellow to Amber to Dark green
• Merck: 14,1375
• CAS DataBase Reference: 59803-98-4(CAS DataBase Reference)

Description and Uses

Launched in the US for open-angle glaucoma and ocular hypertension, brimonidine is a relatively selective and potent α_2a,-adrenergic agonist with low affinity for the imidazoline l₁ receptor. Topical application reduces intraocular pressure. This bypasses any central hypotensive effects at the l₁ receptor (which can also give rise to a decrease in blood pressure and heart rate) if given systemically, since topical application results in low plasma levels concomitant with rapid systemic elimination. Brimonidine can be prepared in a four-step sequence from 4-nitrophenylenediamine.

a2-Adrenoceptor agonist. Antiglaucoma

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P301+P310
• Hazard Codes: T
• Risk Statements: 25-36/37/38
• Safety Statements: 26-36-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: -
• RTECS: VD1200000
• HazardClass: 6.1
• PackingGroup: Ⅲ
• HS Code: 29332900