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A7087558

Brimonidine , 10mMinDMSO , 59803-98-4

Synonym(s):
5-Bromo-N-(2-imidazolin-2-yl)-6-quinoxalinamine;5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine;Brimonidine

CAS NO.:59803-98-4

Empirical Formula: C11H10BrN5

Molecular Weight: 292.13

MDL number: MFCD00153878

EINECS: 000-000-0

Pack Size Price Stock Quantity
1ml RMB399.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 207.5 °C
Boiling point: 432.6±55.0 °C(Predicted)
Density  1.82±0.1 g/cm3(Predicted)
storage temp.  Keep in dark place,Sealed in dry,2-8°C
solubility  45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8 mg/mL
form  powder to crystal
pka 7.69±0.10(Predicted)
color  Light yellow to Amber to Dark green
Merck  14,1375

Description and Uses

Launched in the US for open-angle glaucoma and ocular hypertension, brimonidine is a relatively selective and potent α2a,-adrenergic agonist with low affinity for the imidazoline l1 receptor. Topical application reduces intraocular pressure. This bypasses any central hypotensive effects at the l1 receptor (which can also give rise to a decrease in blood pressure and heart rate) if given systemically, since topical application results in low plasma levels concomitant with rapid systemic elimination. Brimonidine can be prepared in a four-step sequence from 4-nitrophenylenediamine.

a2-Adrenoceptor agonist. Antiglaucoma

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25-36/37/38
Safety Statements  26-36-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  -
RTECS  VD1200000
HazardClass  6.1
PackingGroup 
HS Code  29332900

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