LN7684729
98% , 103745-39-7
Synonym(s):
Fasudil, (5-Isoquinolinesulfonyl)homopiperazine, 2HCl, PKG Inhibitor VII;HA 1077, Dihydrochloride - CAS 103745-39-7 - Calbiochem
CAS NO.：103745-39-7
Empirical Formula: C14H17N3O2S
Molecular Weight: 291.37
MDL number: MFCD00153805
EINECS: 816-154-4
| Pack Size | Price | Stock | Quantity |
| 250mg | RMB144.00 | In Stock |
|
| 1g | RMB448.00 | In Stock |
|
| 5g | RMB1584.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 506.2±60.0 °C(Predicted) |
| Density | 1.289±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | H2O: >200 mg/mL |
| form | solid |
| pka | 9.73±0.20(Predicted) |
| color | white |
| Water Solubility | Soluble in water or DMSO |
| CAS DataBase Reference | 103745-39-7(CAS DataBase Reference) |
Description and Uses
A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced co ntraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho- associated Kinase (ROCK IC50= 10.7 uM).
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
| RTECS | HM4031166 |
| HS Code | 29334900 |
| Toxicity | mouse,LD50,unreported,73500ug/kg (73.5mg/kg),United States Patent Document. Vol. #4678783, |
