Icotinib , ≥99% , 610798-31-7

CAS NO.：610798-31-7

Empirical Formula: C22H21N3O4

Molecular Weight: 391.42

MDL number: MFCD22124501

EINECS: 1592732-453-0

PRODUCT Properties

• Boiling point: 581℃
• Density: 1.31
• Flash point: 305℃
• storage temp.: Store at -20°C
• solubility: insoluble in H2O; ≥129.6 mg/mL in DMSO; ≥14.13 mg/mL in EtOH with ultrasonic
• form: Powder
• pka: 5.32±0.20(Predicted)
• color: White to off-white

Description and Uses

Icotinib is also known as ConMana. It is a highly selective, first-generation inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR-TKI), whose mutation and overexpression is involved in many kinds of cancer. Icotinib is a quinazoline derivative that binds reversibly to the ATP binding site of the EGFR protein, being capable of blocking the signal transduction cascade. It is currently under investigation for its treatment efficacy on the EGFR+ Non-small cell lung cancer.

Icotinib is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with IC50 of 5 nM.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P330-P501
• HS Code: 29339900