Home Categories Biochemical Engineering Barasertib (AZD1152-HQPA)
A0778812

Barasertib (AZD1152-HQPA) , ≥97% , 722544-51-6

Synonym(s):
3-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-5-acetamide

CAS NO.:722544-51-6

Empirical Formula: C26H30FN7O3

Molecular Weight: 507.56

MDL number: MFCD10687152

Pack Size Price Stock Quantity
10MG RMB586.40 In Stock
50MG RMB2399.20 In Stock
250MG RMB7199.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Boiling point: 796.7±60.0 °C(Predicted)
Density  1.359±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: >15mg/mL
pka 13.07±0.10(Predicted)
form  powder
color  white to beige
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey QYZOGCMHVIGURT-UHFFFAOYSA-N
CAS DataBase Reference 722544-51-6

Description and Uses

AZD1152-HQPA (722544-51-6) is a potent and highly selective inhibitor of Aurora B.1?Aurora B Ki?= 0.36 nM; Aurora A Ki?= 1,369 nM.2?It inhibits the growth of tumors in multiple cancer models.3-6?Excessive ROS generation7?and upregulated tumor suppressor miRNAs8?have been proposed as a novel mechanisms of cytotoxicity of AZD1152-HQPA.

AZD1152-HQPA has been used:

  • for the dose dependent inhibition of aurora kinase B (AURKB)
  • as a component to identify that, replication timing regulatory factor 1 (RIF1) and protein phosphatase 1 (PP1) are critical for the regulation of abscission timing in human cells
  • as a component to study the relevance of AURKB as a cancer therapeutic target

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
WGK Germany  3

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