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BD3654645

ZofenoprilCalcium , 98% , 81938-43-4

Synonym(s):
(4S)-1-[(2S)-3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-L-proline calcium salt

CAS NO.:81938-43-4

Empirical Formula: C44H44CaN2O8S4

Molecular Weight: 897.167

MDL number: MFCD08704648

Pack Size Price Stock Quantity
250mg RMB216.80 In Stock
1g RMB471.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: >250°C
alpha  D23 -67.6° (c = 1 in methanol/HCl)
storage temp.  Inert atmosphere,2-8°C
solubility  DMSO: >5mg/mL
form  powder
color  white to off-white
CAS DataBase Reference 81938-43-4(CAS DataBase Reference)

Description and Uses

Zofenopril is a prodrug form of the angiotensin-converting enzyme (ACE) inhibitor zofenoprilat. Zofenopril is hydrolyzed by cardiac esterases in vivo to form zofenoprilat. It inhibits ACE with an IC50 value of 0.9 nM in heart tissue homogenates and inhibits cardiac ACE activity in isolated perfused rat hearts. It reduces mean arterial blood pressure in two kidney-one clip renal hypertensive (2K-1C) rats and spontaneously hypertensive rats (SHRs) when administered at doses of 2.2, 6.6, and 22 mg/kg. Unlike the ACE inhibitor ramipril , zofenopril does not affect bronchoalveolar lavage fluid (BALF) levels of bradykinin or prostaglandin E2 (PGE2; ) or increase coughing induced by citric acid in guinea pigs.

Angiotensin-converting enzyme ACE inhibitor. A prodrug that is de-esterified to the active inhibitor, the sulfhydryl group containing metabolite, Zofenoprilat

Safety

Symbol(GHS) 
GHS09
Signal word  Warning
Hazard statements  H410
Precautionary statements  P273-P501
Hazard Codes  N
Risk Statements  50/53
Safety Statements  60-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
HS Code  2933.99.5300

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