Levofloxacin , >98.0%(HPLC) , 100986-85-4

Synonym(s):
(−)-Ofloxacin;Levofloxacin hemihydrate

CAS NO.：100986-85-4

Empirical Formula: C18H20FN3O4

Molecular Weight: 361.37

MDL number: MFCD03265511

EINECS: 600-146-0

PRODUCT Properties

• Melting point: 218°C
• Boiling point: 572℃
• Density: 1.48±0.1 g/cm3(Predicted)
• Flash point: >110°(230°F)
• storage temp.: Keep in dark place,Sealed in dry,2-8°C
• solubility: chloroform: soluble10mg/mL
• pka: 5.19±0.40(Predicted)
• form: powder
• color: white to faint yellow
• optical activity: [α]20/D -104±4° in chloroform
• Water Solubility: Slightly soluble in water or methanol. Soluble in glacial acetic acid or dichloromethane
• Sensitive: Light Sensitive
• Merck: 14,6771
• BRN: 7327015
• BCS Class: 3,1
• InChIKey: GSDSWSVVBLHKDQ-JTQLQIEISA-N
• CAS DataBase Reference: 100986-85-4(CAS DataBase Reference)
• EPA Substance Registry System: 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (3S)- (100986-85-4)

Description and Uses

Levofloxacin, the optically active S-isomer of the fluoroquinolone antibiotic ofloxacin, is two to four times more potent than ofloxacin with reportedly less side effects in treating infections of the lower respiratory and urinary tract, prostate infections and sexually transmitted diseases. It has broad and potent antibacterial activity over common Grampositive and -negative aerobic pathogens and obligate anaerobes. Different from the cephem antibiotics, levofloxacin is unique in its marked selectivity against members of the family Enterobacteriaceae and its negligible effect on predominant anaerobes. Levofloxacin also exhibits satisfactory antimicrobial effects in surgical infections and it may be used for treatment of gastrointestinal infections such as traveler’s diarrhea associated with the pathogenic Enterobacteriaceae.

Levofloxacin is a broad-spectrum antibiotic used in pharmacokinetic?, antibiotic resistance?, and resistance prevention?studies. Levofloxacin is active against Gram-positive and Gram-negative bacteria. It inhibits DNA gyrase (type II topoisomerase) and topoisomerase IV, thereby inhibiting cell division.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H302-H317-H334
• Precautionary statements: P261-P264-P270-P280-P301+P312-P302+P352
• Hazard Codes: Xn
• Risk Statements: 22-42/43-68-20/21/22-64-63
• Safety Statements: 26-36/37/39-36
• RIDADR: UN 1648 3 / PGII
• WGK Germany: 3
• RTECS: UU8815550
• HS Code: 29349990
• Hazardous Substances Data: 100986-85-4(Hazardous Substances Data)
• Toxicity: LD50 oral in rat: 1478mg/kg