Deoxynivalenol Quality Control Sample,From wheat , 188ppb(±78ppb) , 51481-10-8

Synonym(s):
DON;Vomitoxin;DON solution;RD-toxon;(3α,7α)-3,7,15-trihydroxy-12,13-epoxytrichothec-9-en-8-one

CAS NO.：51481-10-8

Empirical Formula: C15H20O6

Molecular Weight: 296.32

MDL number: MFCD00078777

EINECS: 610-668-0

PRODUCT Properties

• Melting point: 151-153 C
• alpha: D25+6.35° (c = 0.07 in ethanol)
• Boiling point: 357.92°C (rough estimate)
• Density: 1.48
• refractive index: 1.4359 (estimate)
• Flash point: -3 °C
• storage temp.: -20°C
• solubility: DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
• form: solution (ethanol: 2-propanol 95:5)
• pka: 11.91±0.70(Predicted)
• color: White to off-white
• Merck: 13,10092
• Stability: Stable. Incompatible with strong oxidizing agents.
• InChI: InChI=1/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/s3
• InChIKey: LINOMUASTDIRTM-QUKTVYMZNA-N
• SMILES: [C@@]12(CO1)[C@@]1([H])[C@H](O)C[C@]2(C)[C@@]2(CO)[C@H](O)C(C(C)=C[C@@]2([H])O1)=O |&1:0,3,5,8,10,13,19,r|
• LogP: -1.250 (est)
• CAS DataBase Reference: 51481-10-8

Description and Uses

Vomitoxin or deoxynivalenol (DON) is one of the trichothecenes (mycotoxins) which comprise a large group (148 or more have been identified) of protein synthesis inhibitors. These mycotoxins are also powerful immunosuppressants which may predispose animals to other diseases.
Vomitoxin is the most commonly found trichothecene in moldy corn (maize), but a number of other biologically active trichothecenes are produced by species of the fungus Fusarium. These include nivalenol, T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS), and monoacetoxyscipenol (MAS). These mycotoxins are most toxic when fed to swine and other monogastric animals including humans. Poultry are generally more resistant to trichothecenes than hogs, whereas T-2 toxin and DAS appear to be more toxic to chickens than vomitoxin. Toxins already present in corn at harvest may increase in stored ear corn. Extended periods of warm, rainy, or damp weather from flowering time onward promote infection of corn by Fusarium species (1–7).

Deoxynivalenol solution has been used as an analytical reference standard for the quantification of the analyte in cornmeal and wheat meal matrices using high-performance liquid chromatography with UV detection (HPLC-UV). It is used as an analytical standard in investigating its toxicity mechanism on human chondrocytes by microarray and bioinformatics analysis.

Safety

• Symbol(GHS): GHS02,GHS07,GHS08
• Signal word: Danger
• Hazard statements: H225-H319-H336-H371
• Precautionary statements: P210-P305+P351+P338-P308+P311
• Hazard Codes: T,Xn,F,Xi
• Risk Statements: 25-68/20/21/22-67-66-36-20/21/22-11-36/37/38
• Safety Statements: 36/37/39-45-36-26-16-36/37-37/39
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• RTECS: YD0167000
• HazardClass: 6.1(a)
• PackingGroup: I
• HS Code: 29329990
• Hazardous Substances Data: 51481-10-8(Hazardous Substances Data)
• Toxicity: LD50 i.p. in male, female mice (mg/kg): 70.0, 76.7 (Yoshizawa, Morooka)