Atropine , 10mMinDMSO , 51-55-8

Synonym(s):
Atropine;Atropine solution;endo-(±)-α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester;Hyoscyamine;Tropine tropate

CAS NO.：51-55-8

Empirical Formula: C17H23NO3

Molecular Weight: 289.37

MDL number: MFCD00022622

EINECS: 200-104-8

PRODUCT Properties

• Melting point: 115-118 °C
• Boiling point: 431.53°C (rough estimate)
• Density: 1.0470 (rough estimate)
• refractive index: 1.5200 (estimate)
• Flash point: 2℃
• storage temp.: -20°C
• solubility: H₂O: 2 mg/mL
• form: powder
• pka: 9.7(at 21℃)
• color: white
• Water Solubility: 1.6g/L(18 ºC)
• Sensitive: Light Sensitive
• Merck: 14,875
• BRN: 91260
• InChIKey: RKUNBYITZUJHSG-SPUOUPEWSA-N

Description and Uses

Atropine is a naturally occurring tropane alkaloid extracted from plants of the family Solanaceae including deadly nightshade (A. belladonna). It is a non-selective, competitive antagonist of the muscarinic acetylcholine receptor types M₁, M₂, M₃, M₄, and M₅ (pKBs range from 8.9-9.8). Atropine increases firing of the sinoatrial node and conduction through the atrioventricular node of the heart, opposes the actions of the vagus nerve, blocks acetylcholine receptor sites, and decreases bronchial secretions. It is classified as an anticholinergic (parasympatholytic) drug and commonly used to dilate the pupils, increase heart rate, reduce salivation and other secretions, and as an antidote against organophosphate poisoning.

Scopolamine is found in the leaves of Daturametel L., D. meteloides L., and D. fastuosavar. alba (Cordell 1978). It is used as asedative, a preanesthetic agent, and in thetreatment of motion sickness (Merck 1989).

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H300+H330
• Precautionary statements: P260-P264-P270-P271-P284-P304+P340+P310
• Hazard Codes: T+,Xn,F
• Risk Statements: 26/28-36/37/38-20/21/22-36-11
• Safety Statements: 25-45-36-26-36/37-16
• RIDADR: 1544
• WGK Germany: 3
• RTECS: CK0700000
• F: 8-10-23
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 29399900
• Toxicity: LD50 orally in rats: 750 mg/kg (Cahen, Tvede)