T-2 TOXIN-13C24 , 25μg/mLinacetonitrile , 21259-20-1

Synonym(s):
12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol-4,15-diacetate-8-isovalerate;4β,15-Diacetoxy-3α-hydroxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene

CAS NO.：21259-20-1

Empirical Formula: C24H34O9

Molecular Weight: 466.53

MDL number: MFCD00871255

EINECS: 244-297-7

PRODUCT Properties

• Melting point: 151.5℃
• alpha: D26 +15° (c = 2.58 in ethanol)
• Boiling point: 489.35°C (rough estimate)
• Density: 1.1942 (rough estimate)
• refractive index: 1.6230 (estimate)
• Flash point: 2 °C
• storage temp.: −20°C
• solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 20 mg/ml
• form: powder
• pka: 13.24±0.70(Predicted)
• color: white
• Merck: 13,9872
• IARC: 3 (Vol. 31, Sup 7) 1987

Description and Uses

T-2 toxin is a trichothecene mycotoxin that has been found in Fusarium. It binds to and inhibits peptidyltransferase in the 60S ribosomal subunit, inducing a ribotoxic stress response that triggers JNK and p38 MAPK signaling. T-2 toxin (3 nM) decreases toll-like receptor expression and LPS-induced production of IL-1β, TNF-α, and nitric oxide (NO) in, and is cytotoxic to (IC₅₀ = 19.47), primary pig alveolar macrophages (PAMs). In vivo, T-2 toxin induces production of reactive oxygen species (ROS), lipid peroxidation, and glutathione (GSH) depletion in mouse brain and is lethal to mice (LD₅₀s = 1.54-5.94 mg/kg). It also induces hepatocyte apoptosis and dyslipidemias in mice. T-2 toxin has been found in Fusarium-infected wheat, barley, and rice crops both in fields and in storage.

T-2 Toxin is a tricothecene mycotoxin produced by fungi of the genus Fusarium. T-2 Toxin induces DNA damage and cell death on prolonged administration.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H300+H310+H330-H315
• Precautionary statements: P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310
• Hazard Codes: T+,T,Xn,F
• Risk Statements: 26/27/28-38-36-20/21/22-11
• Safety Statements: 28-36/37-45-36-26-16-36/37/39-22
• RIDADR: UN 3462 6.1/PG 1
• WGK Germany: 3
• RTECS: YD0100000
• F: 10-21
• HazardClass: 6.1(a)
• PackingGroup: I
• HS Code: 29329990
• Hazardous Substances Data: 21259-20-1(Hazardous Substances Data)
• Toxicity: LD50 orally in female rats: 4.0 mg/kg (Marasas); LD50 (mg/kg) in mice: 5.2 i.p., 4.2 i.v.; in rats: 7.0 intragastric, 0.9-1.3 i.p., 0.9 i.v., 2.0 s.c.; in guinea pigs: 3.0-4.0 orally, 5.3 intragastric, 1.0 i.m., 1.0-2.0 i.v., 1.0-2.0 s.c.; in pigs: 5.0 orally, 3.0 i.v. (Yagen, Bailer)