Deoxynivalenol-Deoxynivalenol , 25μg/mLinacetonitrile , 51481-10-8
Synonym(s):
DON;Vomitoxin;DON solution;RD-toxon;(3α,7α)-3,7,15-trihydroxy-12,13-epoxytrichothec-9-en-8-one
CAS NO.：51481-10-8
Empirical Formula: C15H20O6
Molecular Weight: 296.32
MDL number: MFCD00078777
EINECS: 610-668-0
| Pack Size | Price | Stock | Quantity |
| 1.2ML | RMB10399.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 151-153 C |
| alpha | D25+6.35° (c = 0.07 in ethanol) |
| Boiling point: | 357.92°C (rough estimate) |
| Density | 1.48 |
| refractive index | 1.4359 (estimate) |
| Flash point: | -3 °C |
| storage temp. | -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml |
| form | solution (ethanol: 2-propanol 95:5) |
| pka | 11.91±0.70(Predicted) |
| color | White to off-white |
| Merck | 13,10092 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| InChI | InChI=1/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/s3 |
| InChIKey | LINOMUASTDIRTM-QUKTVYMZNA-N |
| SMILES | [C@@]12(CO1)[C@@]1([H])[C@H](O)C[C@]2(C)[C@@]2(CO)[C@H](O)C(C(C)=C[C@@]2([H])O1)=O |&1:0,3,5,8,10,13,19,r| |
| LogP | -1.250 (est) |
| CAS DataBase Reference | 51481-10-8 |
Description and Uses
Vomitoxin or deoxynivalenol (DON) is one of the
trichothecenes (mycotoxins) which comprise a large
group (148 or more have been identified) of protein
synthesis inhibitors. These mycotoxins are also powerful
immunosuppressants which may predispose animals to
other diseases.
Vomitoxin is the most commonly found
trichothecene in moldy corn (maize), but a number of
other biologically active trichothecenes are produced by
species of the fungus Fusarium. These include nivalenol,
T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS), and
monoacetoxyscipenol (MAS). These mycotoxins are most
toxic when fed to swine and other monogastric animals
including humans. Poultry are generally more resistant
to trichothecenes than hogs, whereas T-2 toxin and DAS
appear to be more toxic to chickens than vomitoxin. Toxins
already present in corn at harvest may increase in stored
ear corn. Extended periods of warm, rainy, or damp
weather from flowering time onward promote infection
of corn by Fusarium species (1–7).
Deoxynivalenol solution has been used as an analytical reference standard for the quantification of the analyte in cornmeal and wheat meal matrices using high-performance liquid chromatography with UV detection (HPLC-UV). It is used as an analytical standard in investigating its toxicity mechanism on human chondrocytes by microarray and bioinformatics analysis.
Safety
| Symbol(GHS) |    GHS02,GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H225-H319-H336-H371 |
| Precautionary statements | P210-P305+P351+P338-P308+P311 |
| Hazard Codes | T,Xn,F,Xi |
| Risk Statements | 25-68/20/21/22-67-66-36-20/21/22-11-36/37/38 |
| Safety Statements | 36/37/39-45-36-26-16-36/37-37/39 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | YD0167000 |
| HazardClass | 6.1(a) |
| PackingGroup | I |
| HS Code | 29329990 |
| Hazardous Substances Data | 51481-10-8(Hazardous Substances Data) |
| Toxicity | LD50 i.p. in male, female mice (mg/kg): 70.0, 76.7 (Yoshizawa, Morooka) |
