Home Categories Analytical Chemistry Deoxynivalenol-Deoxynivalenol
A8347432

Deoxynivalenol-Deoxynivalenol , 25μg/mLinacetonitrile , 51481-10-8

Synonym(s):
DON;Vomitoxin;DON solution;RD-toxon;(3α,7α)-3,7,15-trihydroxy-12,13-epoxytrichothec-9-en-8-one

CAS NO.:51481-10-8

Empirical Formula: C15H20O6

Molecular Weight: 296.32

MDL number: MFCD00078777

EINECS: 610-668-0

Pack Size Price Stock Quantity
1.2ML RMB10399.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 151-153 C
alpha  D25+6.35° (c = 0.07 in ethanol)
Boiling point: 357.92°C (rough estimate)
Density  1.48
refractive index  1.4359 (estimate)
Flash point: -3 °C
storage temp.  -20°C
solubility  DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
form  solution (ethanol: 2-propanol 95:5)
pka 11.91±0.70(Predicted)
color  White to off-white
Merck  13,10092
Stability: Stable. Incompatible with strong oxidizing agents.
InChI InChI=1/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/s3
InChIKey LINOMUASTDIRTM-QUKTVYMZNA-N
SMILES [C@@]12(CO1)[C@@]1([H])[C@H](O)C[C@]2(C)[C@@]2(CO)[C@H](O)C(C(C)=C[C@@]2([H])O1)=O |&1:0,3,5,8,10,13,19,r|
LogP -1.250 (est)

Description and Uses

Vomitoxin or deoxynivalenol (DON) is one of the trichothecenes (mycotoxins) which comprise a large group (148 or more have been identified) of protein synthesis inhibitors. These mycotoxins are also powerful immunosuppressants which may predispose animals to other diseases.
Vomitoxin is the most commonly found trichothecene in moldy corn (maize), but a number of other biologically active trichothecenes are produced by species of the fungus Fusarium. These include nivalenol, T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS), and monoacetoxyscipenol (MAS). These mycotoxins are most toxic when fed to swine and other monogastric animals including humans. Poultry are generally more resistant to trichothecenes than hogs, whereas T-2 toxin and DAS appear to be more toxic to chickens than vomitoxin. Toxins already present in corn at harvest may increase in stored ear corn. Extended periods of warm, rainy, or damp weather from flowering time onward promote infection of corn by Fusarium species (1–7).

Deoxynivalenol solution has been used as an analytical reference standard for the quantification of the analyte in cornmeal and wheat meal matrices using high-performance liquid chromatography with UV detection (HPLC-UV). It is used as an analytical standard in investigating its toxicity mechanism on human chondrocytes by microarray and bioinformatics analysis.

Safety

Symbol(GHS) 
GHS02,GHS07,GHS08
Signal word  Danger
Hazard statements  H225-H319-H336-H371
Precautionary statements  P210-P305+P351+P338-P308+P311
Hazard Codes  T,Xn,F,Xi
Risk Statements  25-68/20/21/22-67-66-36-20/21/22-11-36/37/38
Safety Statements  36/37/39-45-36-26-16-36/37-37/39
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  YD0167000
HazardClass  6.1(a)
PackingGroup  I
HS Code  29329990
Toxicity LD50 i.p. in male, female mice (mg/kg): 70.0, 76.7 (Yoshizawa, Morooka)

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