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A7784458

(-)-HuperzineA , 2mMinDMSO , 102518-79-6

Synonym(s):
(−)-Selagine;Kimpukan A

CAS NO.:102518-79-6

Empirical Formula: C15H18N2O

Molecular Weight: 242.32

MDL number: MFCD01714949

EINECS: 600-320-6

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 211-216oC
alpha  D -147° (c = 0.36 in CH3OH) (Ayer); D24.5 -150.4° (c = 0.498 in MeOH) (Liu)
Boiling point: 505.0±50.0 °C(Predicted)
Density  1.20±0.1 g/cm3(Predicted)
storage temp.  Keep in dark place,Inert atmosphere,2-8°C
solubility  insoluble in H2O; ≥12.12 mg/mL in DMSO; ≥23.13 mg/mL in EtOH
form  Solid
pka 12.25±0.60(Predicted)
color  White to Almost white
optical activity [α]/D -153±5°, c = 0.5 in methanol
InChI InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1
InChIKey ZRJBHWIHUMBLCN-YQEJDHNASA-N
SMILES C12C[C@@]3([H])/C(=C\C)/[C@@](N)(C=1C=CC(=O)N2)CC(C)=C3
LogP 0.833 (est)

Description and Uses

Huperzine A is obtained from Huperzia serrata, which is the perennial fern. It shows activities in antipyretic, hemostasis, and dehumidification and is used for the treatment in folk of pneumonia, lung abscess, hematemesis, hematochezia, traumatic injury, etc.

Huperzine A is a potential therapeutic agent for Alzheimer disease that reversible alkaloid inhibitor of AChE which crosses the blood-brain barrier. It reduces cell death induced by glutamate in primary cultures derived from forebrain, hippocampus, cortex and cere.
In China, it is approved for use in the treatment of Alzheimer’s disease (AD). Huperzine A was classified as a dietary supplement by the FDA in 1997. As a nutraceutical, it is available in American health food stores or via the Internet, labeled as a memory aid.

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300+H310+H330
Precautionary statements  P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310
Hazard Codes  T+
Risk Statements  26/27/28-36/37/38
Safety Statements  26-36/37/39-45
RIDADR  UN 1544 6.1/PG 2
WGK Germany  3
RTECS  PB9185700
HS Code  29339900

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