(−)-Huperzine A , Analysis standard , 102518-79-6
Synonym(s):
(−)-Selagine;Kimpukan A
CAS NO.：102518-79-6
Empirical Formula: C15H18N2O
Molecular Weight: 242.32
MDL number: MFCD01714949
EINECS: 600-320-6
| Pack Size | Price | Stock | Quantity |
| 25MG | RMB319.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 211-216oC |
| alpha | D -147° (c = 0.36 in CH3OH) (Ayer); D24.5 -150.4° (c = 0.498 in MeOH) (Liu) |
| Boiling point: | 505.0±50.0 °C(Predicted) |
| Density | 1.20±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | insoluble in H2O; ≥12.12 mg/mL in DMSO; ≥23.13 mg/mL in EtOH |
| pka | 12.25±0.60(Predicted) |
| form | Solid |
| color | White to Almost white |
| optical activity | [α]/D -153±5°, c = 0.5 in methanol |
| InChI | InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1 |
| InChIKey | ZRJBHWIHUMBLCN-YQEJDHNASA-N |
| SMILES | C12C[C@@]3([H])/C(=C\C)/[C@@](N)(C=1C=CC(=O)N2)CC(C)=C3 |
| LogP | 0.833 (est) |
| CAS DataBase Reference | 102518-79-6(CAS DataBase Reference) |
Description and Uses
Huperzine A is obtained from Huperzia serrata, which is the perennial fern. It shows activities in antipyretic, hemostasis, and dehumidification and is used for the treatment in folk of pneumonia, lung abscess, hematemesis, hematochezia, traumatic injury, etc.
Huperzine A is a potential therapeutic agent for Alzheimer disease that reversible alkaloid inhibitor of AChE which crosses the blood-brain barrier. It reduces cell death induced by glutamate in primary cultures derived from forebrain, hippocampus, cortex and cere.
In China, it is approved for use in the treatment of Alzheimer’s disease (AD). Huperzine A was classified as a dietary supplement by the FDA in 1997. As a nutraceutical, it is available in American health food stores or via the Internet, labeled as a memory aid.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H300+H310+H330 |
| Precautionary statements | P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310 |
| Hazard Codes | T+ |
| Risk Statements | 26/27/28-36/37/38 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 1544 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | PB9185700 |
| HS Code | 29339900 |
