A7727258
KRN-633 , 10mMinDMSO , 286370-15-8
Synonym(s):
KRN-633;N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N′-propyl-urea
CAS NO.：286370-15-8
Empirical Formula: C20H21ClN4O4
Molecular Weight: 416.86
MDL number: MFCD14155620
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 231-232°C |
| Boiling point: | 545.6±50.0 °C(Predicted) |
| Density | 1.321 |
| storage temp. | -20°C |
| solubility | DMSO: soluble3mg/mL, clear (warmed) |
| pka | 13.08±0.70(Predicted) |
| form | powder |
| color | white to beige |
Description and Uses
KRN 633 is an ATP-competitive inhibitor of vascular endothlial growth factor receptor tyrosine kinase (VEGFR). KRN 633 also suppresses VEGF-dependent activation of MAPK and cell proliferation and demonstrates antitumor and antiangiogenic activity by inhibiting vessel formation and vascular permeability in human tumor xenograft models.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 3 |
