Ki8751 , ≥98% , 228559-41-9

Synonym(s):
N-(2,4-Difluorophenyl)-N?-(4-(6,7-dimethoxy-4-quinolyloxy)-2-fluorophenyl)urea, Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor VI, VEGFR Tyrosine Kinase Inhibitor XXIV;VEGFR2 Kinase Inhibitor VI, Ki8751 - CAS 228559-41-9 - Calbiochem

CAS NO.：228559-41-9

Empirical Formula: C24H18F3N3O4

Molecular Weight: 469.41

MDL number: MFCD09971092

PRODUCT Properties

• Melting point: 239℃
• Density: 1.429
• storage temp.: −20°C
• solubility: Soluble in DMSO (15 mg/ml)
• form: Off-white solid
• color: White
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Description and Uses

Ki8751 (228559-41-9) is a very potent (IC50 = 0.9 nM) inhibitor of vascular endothelial growth factor receptor 2 (VEGFR-2).1 It also inhibited PDGFRα (IC50 = 67 nM), c-Kit (IC50 = 40 nM), and FGFR2 (IC50 = 170 nM). Ki8751 completely suppressed HUVEC growth at 1 nM. Ki8751 completely inhibited tumor growth in LC-6 human tumor xenografts @ 5mg/kg. Ki8751 displayed anti-influenza A and B activity via disruption of virus entry in a PDGFR?/GM3-dependent manner.2

Ki8751 is a potent and selective inhibitor of VEGFR2, PDGFRα and c-Kit with IC50 of 0.9 nM, 67 nM and 40 nM, respectively.

Safety

• Hazard Codes: Xn
• Risk Statements: 22-38
• Safety Statements: 37