A7698658
Kenpaullone , 10mMinDMSO , 142273-20-9
Synonym(s):
9-Bromo-7,12-dihydro-indolo-[3,2-d]-[1]benzazepin-6(5H)-one;9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one, NSC-664704;Kenpaullone - CAS 142273-20-9 - Calbiochem;NSC 664704
CAS NO.：142273-20-9
Empirical Formula: C16H11BrN2O
Molecular Weight: 327.18
MDL number: MFCD02683595
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB479.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | >300°C (dec.) |
| Boiling point: | 613.0±45.0 °C(Predicted) |
| Density | 1.596±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 18 mg/mL, clear, yellow |
| pka | 14.29±0.20(Predicted) |
| form | Yellow-brown solid |
| color | yellow |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| InChIKey | QQUXFYAWXPMDOE-UHFFFAOYSA-N |
| CAS DataBase Reference | 142273-20-9(CAS DataBase Reference) |
Description and Uses
Kenpaullone (142273-20-9) inhibits GSK-3β (IC50=0.23 μM) as well as several cyclin-dependent kinases (CDKs), IC50=0.4, 0.68 and 0.85 μM for cdk1, cdk2 and cdk5 respectively.1-3 Induces pluripotent stem cells from somatic cells4 and increases direct neural conversion of human fibroblasts5 when used with other small molecules. Inhibits Kruppel-Like Factor 4 (KLF4) reducing autoimmune arthritis in the collagen-induced arthritis mouse model.6
Kenpaullone has been used:
- as a glycogen synthase kinase 3 (GSK3)/ cyclin-dependent kinase (CDK) inhibitor to study its effects on human neural progenitor cell lines
- as an inhibitor of Krupple-like factor 4 (KLF4) in Gs-coupled designer GPCR (Gs DREADD= GsD) Agouti-related peptide (GsD-AgRP) mice
- as a GSK3/CDK inhibitor to study its effects on the sea urchin embryo development
