Home Categories Indirubin-3′-oxime
A7584058

Indirubin-3′-oxime , 10mMinDMSO , 160807-49-8

Synonym(s):
Indirubin-3ʹ-monoxime - CAS 160807-49-8 - Calbiochem;Indirubin-3′-monoxime

CAS NO.:160807-49-8

Empirical Formula: C16H11N3O2

Molecular Weight: 277.28

MDL number: MFCD02683594

Pack Size Price Stock Quantity
1ml RMB559.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 247-249°C
Boiling point: 532.2±50.0 °C(Predicted)
Density  1.50
storage temp.  room temp
solubility  DMSO: >10 mg/mL
form  solid
pka 8.66±0.20(Predicted)
color  Dark red or brown
Stability: Light Sensitive
CAS DataBase Reference 160807-49-8

Description and Uses

Indirubin-3’-oxime is a potent inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 22 nM). As GSK3β phosphorylates tau protein, indirubin-3’-oxime prevents tau phosphorylation both in vitro and in vivo at Alzheimer’s disease-relevant sites. It also inhibits cyclin-dependent kinases (CDKs) at higher concentrations, including Cdk1/cyclin B (IC50 = 180 nM), Cdk2/cyclin A (IC50 ~500 nM), Cdk2/cyclin E (IC50 = 250nM), Cdk4/cyclin D1 (IC50 = 3.3 μM) and Cdk5/p35 (IC50 = 100 nM). Indirubin-3’-oxime reversibly inhibits the proliferation of many cells types, arresting cycling in the G2/M phase.

Indirubin-3′-oxime has been used in the inhibition of glycogen synthase kinase 3 in human monocytic cell line, THP-1.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
WGK Germany  3

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