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A5242512

Kenpaullone , >97.0%(HPLC) , 142273-20-9

Synonym(s):
9-Bromo-7,12-dihydro-indolo-[3,2-d]-[1]benzazepin-6(5H)-one;9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one, NSC-664704;Kenpaullone - CAS 142273-20-9 - Calbiochem;NSC 664704

CAS NO.:142273-20-9

Empirical Formula: C16H11BrN2O

Molecular Weight: 327.18

MDL number: MFCD02683595

Pack Size Price Stock Quantity
5MG RMB119.20 In Stock
10mg RMB215.20 In Stock
50mg RMB799.20 In Stock
100MG RMB1439.20 In Stock
250mg RMB3199.20 In Stock
1g RMB7999.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: >300°C (dec.)
Boiling point: 613.0±45.0 °C(Predicted)
Density  1.596±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: 18 mg/mL, clear, yellow
pka 14.29±0.20(Predicted)
form  Yellow-brown solid
color  yellow
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey QQUXFYAWXPMDOE-UHFFFAOYSA-N
CAS DataBase Reference 142273-20-9(CAS DataBase Reference)

Description and Uses

Kenpaullone (142273-20-9) inhibits GSK-3β (IC50=0.23 μM) as well as several cyclin-dependent kinases (CDKs), IC50=0.4, 0.68 and 0.85 μM for cdk1, cdk2 and cdk5 respectively.1-3 Induces pluripotent stem cells from somatic cells4 and increases direct neural conversion of human fibroblasts5 when used with other small molecules. Inhibits Kruppel-Like Factor 4 (KLF4) reducing autoimmune arthritis in the collagen-induced arthritis mouse model.6

Kenpaullone has been used:

  • as a glycogen synthase kinase 3 (GSK3)/ cyclin-dependent kinase (CDK) inhibitor to study its effects on human neural progenitor cell lines
  • as an inhibitor of Krupple-like factor 4 (KLF4) in Gs-coupled designer GPCR (Gs DREADD= GsD) Agouti-related peptide (GsD-AgRP) mice
  • as a GSK3/CDK inhibitor to study its effects on the sea urchin embryo development

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HS Code  2933.79.1500

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