Indirubin-3′-oxime , ≥98%(HPLC) , 160807-49-8

Synonym(s):
Indirubin-3ʹ-monoxime - CAS 160807-49-8 - Calbiochem;Indirubin-3′-monoxime

CAS NO.：160807-49-8

Empirical Formula: C16H11N3O2

Molecular Weight: 277.28

MDL number: MFCD02683594

PRODUCT Properties

• Melting point: 247-249°C
• Boiling point: 532.2±50.0 °C(Predicted)
• Density: 1.50
• storage temp.: room temp
• solubility: DMSO: >10 mg/mL
• form: solid
• pka: 8.66±0.20(Predicted)
• color: Dark red or brown
• Stability: Light Sensitive

Description and Uses

Indirubin-3’-oxime is a potent inhibitor of glycogen synthase kinase 3β (GSK3β; IC₅₀ = 22 nM). As GSK3β phosphorylates tau protein, indirubin-3’-oxime prevents tau phosphorylation both in vitro and in vivo at Alzheimer’s disease-relevant sites. It also inhibits cyclin-dependent kinases (CDKs) at higher concentrations, including Cdk1/cyclin B (IC₅₀ = 180 nM), Cdk2/cyclin A (IC₅₀ ~500 nM), Cdk2/cyclin E (IC₅₀ = 250nM), Cdk4/cyclin D1 (IC₅₀ = 3.3 μM) and Cdk5/p35 (IC₅₀ = 100 nM). Indirubin-3’-oxime reversibly inhibits the proliferation of many cells types, arresting cycling in the G₂/M phase.

Indirubin-3′-oxime has been used in the inhibition of glycogen synthase kinase 3 in human monocytic cell line, THP-1.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H332-H335
• Precautionary statements: P261-P280-P305+P351+P338
• WGK Germany: 3