10-Hydroxycamptothecin , 10mMinDMSO , 64439-81-2
Synonym(s):
10-Hydroxycamptothecin, HCPT;Camptothecin, 10-Hydroxy-, Camptotheca acuminata - CAS 64439-81-2 - Calbiochem
CAS NO.：64439-81-2
Empirical Formula: C20H16N2O5
Molecular Weight: 364.35
MDL number: MFCD00274425
EINECS: 613-598-9
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 230-237°C |
| Boiling point: | 820.7±65.0 °C(Predicted) |
| Density | 1.60 |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO: ≥ 37.5 mg/mL (102.92 mM) |
| form | Pale yellow powder |
| pka | 8.93±0.40(Predicted) |
| color | Yellow |
| InChI | InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3 |
| InChIKey | LCZZWLIDINBPRC-FQEVSTJZSA-N |
| SMILES | N1C2C(=CC(O)=CC=2)C=C2CN3C(C=12)=CC1C(CC)(O)C(=O)OCC=1C3=O |
| CAS DataBase Reference | 64439-81-2(CAS DataBase Reference) |
Description and Uses
10-Hydroxycamptothecin: An Inhibitor of Topoisomerase I with Antitumor Activity
10-hydroxycamptothecin (10-HCPT) is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. 10-HCPT, a member of the camptothecin family, interferes with DNA synthesis by inhibiting the enzyme topoisomerase-I and has a broad spectrum of antitumor activity and less toxicity as camptothecins. However, 10-HCPT is insoluble in both water and physiological acceptable organic solvents and tends to change into its carboxylate form, which shows minimal antitumor activity and several unpredictable side effects. Therefore, appropriate drug delivery systems (DDS) for 10-HPCT have been developed to improve the stability of its lactone form. 10-HCPT is also an important precursor for the synthesis of clinically useful anticancer agents, such as irinotecan[1].
Topoisomerase inhibitor
Safety
| Symbol(GHS) |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H301-H340 |
| Precautionary statements | P202-P264-P270-P280-P301+P310-P405 |
| Hazard Codes | Xi,T |
| Risk Statements | 36/37/38-25 |
| Safety Statements | 26-36-45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| RTECS | UQ0491000 |
