(S)-(+)-Camptothecin , Analysis of standard products, ≥98% , 7689-03-4
Synonym(s):
(S)-4-Ethyl-4-hydroxy-1H-pyrano-[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CAS NO.：7689-03-4
Empirical Formula: C20H16N2O4
Molecular Weight: 348.35
MDL number: MFCD00081076
EINECS: 444-280-6
| Pack Size | Price | Stock | Quantity |
| 20MG | RMB70.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 260 °C (dec.)(lit.) |
| alpha | D25 +31.3° (in chloroform-methanol, 8:2) |
| Boiling point: | 482.73°C (rough estimate) |
| Density | 1.3112 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| storage temp. | 2-8°C |
| solubility | chloroform/methanol (4:1): 4 mg/mL |
| form | solid |
| pka | pKa 10.83 (Uncertain) |
| color | yellow |
| Water Solubility | insoluble |
| Merck | 14,1735 |
| BRN | 631069 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChIKey | VSJKWCGYPAHWDS-FQEVSTJZSA-N |
| LogP | 1.740 |
| CAS DataBase Reference | 7689-03-4(CAS DataBase Reference) |
Description and Uses
Camptothecin is an alkaloid derived from Xi Shu (Camptotheca acuminata), which belongs to Nyssaceae. The traditional Chinese medicine Camptotheca acuminata (Xi Shu) has been collected in the Compilation of Chinese Herbal Medicine, Chinese Materia Medica, and Great Dictionary of Chinese Medicine. Camptotheca acuminata (Xi Shu) is widely distributed in the basin of Yangtze river and the southwestern provinces. The main medicinal parts of Camptotheca acuminata (Xi Shu) are root bark and fruit, which get rid of heat and toxic materials and eliminate the disease.
Antitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent
Safety
| Symbol(GHS) |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H301-H340 |
| Precautionary statements | P202-P264-P270-P280-P301+P310-P405 |
| Hazard Codes | T,Xi,Xn |
| Risk Statements | 36/37/38-25-20/21/22 |
| Safety Statements | 45-36/37/39-26-36 |
| RIDADR | UN 1544 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | UQ0492000 |
| Hazard Note | Irritant |
| HazardClass | 6.1 |
| PackingGroup | Ⅲ |
| HS Code | 29399990 |
