Home Categories API 7-Ethyl-10-hydroxycamptothecin
A3966412

7-Ethyl-10-hydroxycamptothecin , 98% , 86639-52-3

Synonym(s):
(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione;SN-38

CAS NO.:86639-52-3

Empirical Formula: C22H20N2O5

Molecular Weight: 392.4

MDL number: MFCD06762720

EINECS: 643-093-9

Pack Size Price Stock Quantity
100MG RMB43.20 In Stock
500MG RMB143.20 In Stock
1G RMB237.60 In Stock
5g RMB1023.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 217 °C
Boiling point: 810.3±65.0 °C(Predicted)
Density  1.51±0.1 g/cm3(Predicted)
refractive index  21.5 ° (C=0.2, THF)
storage temp.  2-8°C
solubility  DMSO: soluble1mg/mL
form  powder
pka 9.13±0.40(Predicted)
color  Off-white
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
InChIKey FJHBVJOVLFPMQE-QFIPXVFZSA-N
SMILES N1C2C(=CC(O)=CC=2)C(CC)=C2CN3C(C=12)=CC1[C@](CC)(O)C(=O)OCC=1C3=O
CAS DataBase Reference 86639-52-3(CAS DataBase Reference)

Description and Uses

SN-38 (86639-52-3), also known as 7-Ethyl-10-hydroxycamptothecin, is the active metabolite of CPT-11 that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1.3 μM respectively) but does not affect protein synthesis. SN-38 displays potent antitumor activity against a range of human tumor cell lines (IC50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HeLa cells respectively).

7-ethyl-10-hydroxycamptothecin (SN 38) is a metabolite of Irinotecan, a DNA topoisomerase inhibitor. SN 38 has been used in trials studying the treatment of Cancer, Advanced Solid Tumors, Small Cell Lung Cancer, Metastatic Colorectal Cancer, and Triple Negative Breast Cancer, among others.

Safety

Symbol(GHS) 
GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H360D-H372
Precautionary statements  P202-P260-P264-P270-P301+P312-P308+P313
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  2811
WGK Germany  3
RTECS  UQ0491000
HazardClass  6.1
PackingGroup 
HS Code  29399990

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