7-Ethyl-10-hydroxycamptothecin , 98% , 86639-52-3

Synonym(s):
(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione;SN-38

CAS NO.：86639-52-3

Empirical Formula: C22H20N2O5

Molecular Weight: 392.4

MDL number: MFCD06762720

EINECS: 643-093-9

PRODUCT Properties

• Melting point: 217 °C
• Boiling point: 810.3±65.0 °C(Predicted)
• Density: 1.51±0.1 g/cm3(Predicted)
• refractive index: 21.5 ° (C=0.2, THF)
• storage temp.: 2-8°C
• solubility: DMSO: soluble1mg/mL
• form: powder
• pka: 9.13±0.40(Predicted)
• color: Off-white
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
• InChI: InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
• InChIKey: FJHBVJOVLFPMQE-QFIPXVFZSA-N
• SMILES: N1C2C(=CC(O)=CC=2)C(CC)=C2CN3C(C=12)=CC1[C@](CC)(O)C(=O)OCC=1C3=O

Description and Uses

SN-38 (86639-52-3), also known as 7-Ethyl-10-hydroxycamptothecin, is the active metabolite of CPT-11 that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1.3 μM respectively) but does not affect protein synthesis. SN-38 displays potent antitumor activity against a range of human tumor cell lines (IC50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HeLa cells respectively).

7-ethyl-10-hydroxycamptothecin (SN 38) is a metabolite of Irinotecan, a DNA topoisomerase inhibitor. SN 38 has been used in trials studying the treatment of Cancer, Advanced Solid Tumors, Small Cell Lung Cancer, Metastatic Colorectal Cancer, and Triple Negative Breast Cancer, among others.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H302-H360D-H372
• Precautionary statements: P202-P260-P264-P270-P301+P312-P308+P313
• Hazard Codes: T
• Risk Statements: 25
• Safety Statements: 45
• RIDADR: 2811
• WGK Germany: 3
• RTECS: UQ0491000
• HazardClass: 6.1
• PackingGroup: Ⅲ
• HS Code: 29399990