(S)-10-Hydroxycamptothecin , 98% , 19685-09-7

Synonym(s):
(S)-10-Hydroxycamptothecin;(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

CAS NO.：19685-09-7

Empirical Formula: C20H16N2O5

Molecular Weight: 364.35

MDL number: MFCD00189425

EINECS: 805-668-4

PRODUCT Properties

• Melting point: 265-270°C
• Boiling point: 820.7±65.0 °C(Predicted)
• Density: 1.60
• storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• solubility: ≥23.8 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
• form: powder to crystal
• pka: 8.93±0.40(Predicted)
• color: White to Yellow to Orange
• InChIKey: HAWSQZCWOQZXHI-FQEVSTJZSA-N

Description and Uses

DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways. (S)-10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound. (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC₅₀ = 1.15 μM). In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G₂/M phase.

A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H301-H340
• Precautionary statements: P202-P264-P270-P280-P301+P310-P405
• Safety Statements: 24/25
• HS Code: 29349990