Irinotecan hydrochloride , 98% , 100286-90-6

Synonym(s):
(S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester;[1,4′-Bipiperidine]-1′-carboxylic acid;CPT-11

CAS NO.：100286-90-6

Empirical Formula: C33H39ClN4O6

Molecular Weight: 623.15

MDL number: MFCD01862255

EINECS: 600-054-0

PRODUCT Properties

• Melting point: 250-256°C (dec.)
• Boiling point: 257 °C
• refractive index: 67.7 ° (C=1, H2O)
• storage temp.: 2-8°C
• solubility: Soluble in DMSO or DMF at approximately 20mg/ml. Sparingly soluble in aqueous buffers. /n
• form: Yellow powder
• color: White to yellow
• Water Solubility: Soluble in DMSO at 100mg/ml. Soluble in water at 25mg/ml with warming
• Merck: 5091
• CAS DataBase Reference: 100286-90-6(CAS DataBase Reference)

Description and Uses

lrinotecan hydrochloride, a semi-synthetic, water soluble derivative of the potent anticancer agent camptothecin, was launched in Japan for the treatment of lung, ovarian, and cervical cancers. lrinotecan exerts its antitumor activity via inhibition of topoisomerase I, a cellular enzyme that is involved in maintaining the topographic structure of DNA during the process of translation, transcription, and mitosis. lrinotecan undergoes de-esterification in vivo to yield an active metabolite, SN-38, which is 1000-fold more potent than the parent. Although being much less toxic than camptothecin, a significant number of patients in clinical trials exhibited side effects of leukopenia, diarrhea, nauseahromiting, and alopecia. Combination therapy of irinotecan with another widely used anticancer agent, cisplatin, has been reported to be superior to either agent alone. lrinotecan is in clinical trials for gastrointestinal, breast, skin, colorectal, pancreatic cancers, mesothelioma and non-Hodgkin's lymphoma.

antineoplactic;'inhibitor of topoisomerase I

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312a-P330-P501a
• Hazard Codes: Xn
• Risk Statements: 22
• WGK Germany: 3
• RTECS: DW1060750
• HS Code: 29399990