Irinotecan HCl Trihydrate , ≥98% , 136572-09-3
CAS NO.：136572-09-3
Empirical Formula: C33H45ClN4O9
Molecular Weight: 677.18
MDL number: MFCD01765731
EINECS: 603-967-2
| Pack Size | Price | Stock | Quantity |
| 100MG | RMB119.20 | In Stock |
|
| 250MG | RMB187.20 | In Stock |
|
| 500MG | RMB383.20 | In Stock |
|
| 1g | RMB556.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 250-256°C (dec.) |
| Boiling point: | 257°C(lit.) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml). |
| form | White solid. |
| color | Yellow |
| Water Solubility | Soluble in DMSO at 100mg/ml. Soluble in water at 25mg/ml with warming |
| Merck | 14,5091 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20° for up to 3 months. |
| CAS DataBase Reference | 136572-09-3(CAS DataBase Reference) |
Description and Uses
Irinotecan (136572-09-3) is a semi-synthetic derivative of camptothecin (Cat.# 10-1041) that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38, Cat.# 10-2425), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3
Irinotecan Hydrochloride Trihydrate is a DNA topoisomerase inhibitor.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H302-H372 |
| Precautionary statements | P260-P264b-P270-P301+P312-P314-P330-P403-P501c |
| Risk Statements | 22 |
| Safety Statements | 20/21-22 |
| RTECS | DW1060750 |
| HS Code | 29349990 |
| Toxicity | dog,LD50,intravenous,40mg/kg (40mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. |
