5-Iodo-2′-deoxyuridine , 10mMinDMSO , 54-42-2

Synonym(s):
Idoxuridine;IDU;5-Iodo-2′-deoxyuridine;5-IUdR;IdUrd

CAS NO.：54-42-2

Empirical Formula: C9H11IN2O5

Molecular Weight: 354.1

MDL number: MFCD00134656

EINECS: 200-207-8

PRODUCT Properties

• Melting point: 194 °C (lit.)
• alpha: 280 º (c=1,1M NaOH)
• Density: 1.7911 (estimate)
• refractive index: 30 ° (C=1, 1mol/L NaOH)
• storage temp.: 2-8°C
• solubility: DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
• form: Crystalline Powder
• pka: 8.25(at 25℃)
• color: White to slightly beige
• Water Solubility: 1.6 g/L (20 ºC)
• Sensitive: Air & Light Sensitive
• Merck: 14,4891
• BRN: 30397
• InChIKey: XQFRJNBWHJMXHO-FSDSQADBSA-N

Description and Uses

5-Iodo-2'-deoxyuridine is a nucleoside analog that inhibits the replication of viruses and other DNA-containing organisms. 2'-Deoxy-5-iodouridine also has inhibitory properties on cell nuclei, which may be due to its ability to bind with DNA and prevent the synthesis of RNA or protein.

Idoxuridine is an antiviral agent effective against herpes-simplex infections; in ophthalmie eyedrops, ointments, and solutions.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H315-H319-H335-H341-H361
• Precautionary statements: P201-P302+P352-P305+P351+P338-P308+P313
• Hazard Codes: T,Xn
• Risk Statements: 45-46-61-40-68-62-36/37/38-63
• Safety Statements: 53-45-36-22-36/37-26
• WGK Germany: 3
• RTECS: YU7700000
• F: 8-23
• TSCA: Yes
• HS Code: 29389090
• Toxicity: LD50 i.p. in mice: 2.5 g/kg (Prusoff, 1979)