Ribavirin , 98% , 36791-04-5

Synonym(s):
1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide;1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide, Virazole;Ribavirin;Ribavirin - CAS 36791-04-5 - Calbiochem

CAS NO.：36791-04-5

Empirical Formula: C8H12N4O5

Molecular Weight: 244.21

MDL number: MFCD00058564

EINECS: 636-825-3

PRODUCT Properties

• Melting point: 174-176°C
• alpha: D25 -36.5° (c = 1 in water); D20 -38° (c = 1 in water)
• Boiling point: 387.12°C (rough estimate)
• Density: 1.4287 (rough estimate)
• refractive index: -36 ° (C=1, H2O)
• storage temp.: 2-8°C
• solubility: Freely soluble in water, slightly soluble in ethanol (96 per cent), slightly soluble or very slightly soluble in methylene chloride. It shows polymorphism (5.9).
• form: White solid
• pka: 12.95±0.70(Predicted)
• color: White
• Water Solubility: >=10 g/100 mL at 19 ºC
• Merck: 14,8198
• BCS Class: 3
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
• InChIKey: IWUCXVSUMQZMFG-AFCXAGJDSA-N
• LogP: -2.260 (est)

Description and Uses

Ribavirin is a clinically useful antiviral medication for Hepatitis C, viral hemorrhagic fevers and other RNA and DNA viruses. The exact mechanism of its antiviral activity is uncertain. Various proposals include inhibition of viral polymerase1, RNA mutagenesis2, and inosine monophosphate dehydrogenase (IMPDH) inhibition3. Sensitizes tumor cells to anticancer agents 5-fluorouracil5 and doxorubicin6 via inhibition of eIF4E. Displays efficacy against atypical teratoid/rhabdoid tumors7 and inhibits glioma cell growth8.

Ribavirin is a guanosine analog with antiviral properties against DNA and RNA viruses, including respiratory syncytial virus, hepatitis C, and influenza. It acts as a prodrug that can be activated by either mono- or tri-phosphorylation by cellular kinases. These phosphorylated derivatives of ribavirin have diverse effects on both cellular and viral enzymes, resulting in suppression of viral replication.

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H341-H360FD
• Precautionary statements: P201-P308+P313
• Hazard Codes: T,Xi
• Risk Statements: 61-36/38
• Safety Statements: 53-22-45-37/39-26
• WGK Germany: 3
• RTECS: XZ4250000
• HS Code: 29349990
• Toxicity: LD50 i.p. in mice: 1.3 g/kg; orally in rats: 5.3 g/kg (Witkowski, 1972)