Trifluridine , ≥98% , 70-00-8

Synonym(s):
α,α,α-Trifluorothymidine;2′-Deoxy-5-trifluoromethyluridine;Trifluorothymidine;Trifluorothymine deoxyriboside;Trifluridine

CAS NO.：70-00-8

Empirical Formula: C10H11F3N2O5

Molecular Weight: 296.2

MDL number: MFCD00006534

EINECS: 200-722-8

PRODUCT Properties

• Melting point: 190-193 °C (lit.)
• Density: 1.4365 (estimate)
• refractive index: 50 ° (C=1, H2O)
• storage temp.: 2-8°C
• solubility: Soluble in DMSO (up to 25 mg/ml) or in Water (up to 14 mg/ml)
• form: solid
• pka: pKa 7.85 (Uncertain)
• color: Off-white
• Merck: 14,9687
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.

Description and Uses

Trifluridine (trifluorothymidine, TFT), a fluorinated pyrimidine nucleoside, is an anti-herpesvirus agent and an antitumor antimetabolite agent. It is an analog of thymidine which inhibits thymidylate synthase possesses antiviral and anticancer activity. After phosphorylation by thymidine kinase, it is incorporated into DNA where it induces DNA-damage and interferes with repair enzymes. Enhances frame shift insertion and deletion in CRISPR genome editing in pluripotent stem cells.

Trifluridine is used as anti-herpesvirus antiviral agent in ophthalmie preparations.

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H341-H351-H361d
• Precautionary statements: P201-P202-P280-P308+P313-P405-P501
• Hazard Codes: Xn,Xi
• Risk Statements: 20/21/22-40
• Safety Statements: 22-36
• WGK Germany: 3
• RTECS: XP2087500
• Hazard Note: Keep Cold
• HS Code: 29349990
• Toxicity: LD50 intraperitoneal in mouse: 1931mg/kg