Home Categories API Gemcitabine hydrochloride
A4637012

Gemcitabine hydrochloride , 98% , 122111-03-9

Synonym(s):
2′-Deoxy-2′,2′-difluorocytidine; dFdC;dFdC;dFdCyd;Gemzar (Lilly)

CAS NO.:122111-03-9

Empirical Formula: C9H12ClF2N3O4

Molecular Weight: 299.66

MDL number: MFCD01735988

EINECS: 601-823-3

Pack Size Price Stock Quantity
10MG RMB31.20 In Stock
50MG RMB47.20 In Stock
250MG RMB73.60 In Stock
1G RMB104.00 In Stock
5g RMB384.00 In Stock
25g RMB1792.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: >250°C dec.
alpha  D +48°; 365 +257.9° (c = 1.0 in deuterated water)
storage temp.  2-8°C
solubility  H2O: ≥10mg/mL
form  White powder
color  White
λmax 268nm(H2O)(lit.)
Merck  14,4386
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.

Description and Uses

Gemcitabine is a novel nucleoside analog that was launched in 1995 in the Netherlands for the treatment of non-small cell lung cancer (nsclc) and in Sweden for pancreatic cancer. Gemcitabine is a prodrug which is phosphorylated intracellularly by deoxycytadine kinase to its active forms, the di- and triphosphates which bind to DNA competitively. This insertion inhibits processes required for DNA synthesis and metabolism, the essential function for both cell replication and repair. Furthermore, gemcitabine displays an extraordinary array of self-potentiating mechanisms that increase the concentration and prolong the retention of its active nucleotides in tumor cells. The title compound has shown activity against a wide spectrum of human solid tumors including colon, mammary, breast, bladder cancers. Synergistic activity of gemcitabine with other anticancer agents such as cisplatin has been reported.

An antineoplastic.

Safety

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H360
Precautionary statements  P201-P202-P280-P308+P313-P405-P501
Hazard Codes  Xn,Xi
Risk Statements  21-36/38-46-62-63
Safety Statements  25-26-36/37-53
WGK Germany  3
RTECS  HA3840000
HS Code  29420000

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