Uracil , 99%, for cell culture , 66-22-8

Synonym(s):
2,4(1H,3H)-Pyrimidinedione;2,4-Dihydroxypyrimidine;2,4-Pyrimidinediol;Uracil

CAS NO.：66-22-8

Empirical Formula: C4H4N2O2

Molecular Weight: 112.09

MDL number: MFCD00006016

EINECS: 200-621-9

PRODUCT Properties

• Melting point: >300 °C (lit.)
• Boiling point: 209.98°C (rough estimate)
• Density: 1.4421 (rough estimate)
• refractive index: 1.4610 (estimate)
• storage temp.: 2-8°C
• solubility: Aqueous Acid (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly)
• form: Crystalline Powder
• pka: 9.45(at 25℃)
• color: White to slightly yellow
• Water Solubility: SOLUBLE IN HOT WATER
• Merck: 14,9850
• BRN: 606623
• Stability: Stable. Incompatible with strong oxidizing agents.
• InChIKey: ISAKRJDGNUQOIC-UHFFFAOYSA-N
• LogP: -1.037 (est)

Description and Uses

Uracil is a pyrimidine base and a fundamental component of RNA where it binds to adenine via hydrogen bonds. It is converted into the nucleoside uridine through the addition of a ribose moiety, then to the nucleotide uridine monophosphate by the addition of a phosphate group.

Uracil metabolism levels may serve as a diagnostic for oral cancer. It was shown that measuring the overproduction of the metabolite uracil improves the diagnosis and prognosis of gingival buccal squamous cell carcinoma, one of the most common oral cancers in India. And about 83.09% of the tumour tissues showed significant changes in both uracil and pyrimidine metabolism. Higher levels of uracil in patients with lymph node metastases suggest that the metabolites may increase the cancer's ability to spread. It could also be used as a marker for recurrence follow-up, the researchers said.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
• Hazard Codes: Xi
• Safety Statements: 22-24/25
• WGK Germany: 2
• RTECS: YQ8650000
• TSCA: Yes
• HS Code: 29335990