Jervine , 10mMinDMSO , 469-59-0
Synonym(s):
(3β, 23β)-17,23-Epoxy-3-hydroxyveratraman-11-one;(3β, 23β)-17,23-Epoxy-3-hydroxyveratraman-11-one, 11-Ketocyclopamine, Shh Signaling Antagonist III;11-Ketocyclopamine;Jervine - CAS 469-59-0 - Calbiochem
CAS NO.：469-59-0
Empirical Formula: C27H39NO3
Molecular Weight: 425.6
MDL number: MFCD01684066
EINECS: 207-417-9
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB300.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 242- 244°C |
| alpha | D20 -150° (ethanol) (Saito); D20 -167.6° (chloroform) (Poethke) |
| Boiling point: | 541.31°C (rough estimate) |
| Density | 1.18±0.1 g/cm3 (20 ºC 760 Torr) |
| refractive index | 1.6400 (estimate) |
| storage temp. | −20°C |
| solubility | methanol: >2 mg/mL |
| form | solid |
| pka | 14.98±0.70(Predicted) |
| color | White |
| λmax | 250nm(lit.) |
| Merck | 14,5264 |
| Stability: | Store in Freezer at - 20°C |
Description and Uses
First obtained from Veratrum grandiflorum by Wright and Luff, this alkaloid is
also present in V. album. It was originally given the formula C26H3703N. 2H20,
subsequently altered to that given above by Jacobs and Craig. The base crystallizes from aqueous EtOH in stellate groups of colourless prisms and has [α]D -
147° (EtOH). The hydrochloride (dihydrate) has m.p. 208°C (Wright and Luff)
or 330-334°C (dec.) according to Jacobs and Craig, the latter finding a change
in crystalline form at 280°C. The hydriodide has m.p. 302-5°C; the nitrate and
aurichloride are both crystalline and the picrate melts at 278-284°C. TheN-nitroso derivative has m.p. 246-7°C; the N-acety1 compound, m.p. 161-2°C
and the O,N-diacetyl derivative, m.p. 17 6-7°C.
Treatment with aluminium tert-butoxide gives Δ4-jervone, m.p. 193-4°C;
[α]28D + 28.3° (EtOH), giving an oxime, m.p. 287-9°C and reduced by aluminium isopropoxide to Δ4-jervine, m.p. 203- 2 11°C. Catalytic hydrogenation
with Pd-C yields the dihydro derivative, m.p. 248-251°C; [α]26D - 82° (EtOH).
On further hydrogenation, the tetrahydro compound is formed, m.p. 216-
221°C; [α]28D - 18° (EtOH). Jervine may be reduced by sodium in butanol to
a:-dihydrojervinol, m.p. 223-5°C; [α]27D - 107° (EtOH). The similar reduction
of dihydrojervine yields (3-dihydrojervino1, m.p. 286-9°C; [α]28D-4 C(EtOH). On
Se dehydrogenation, the alkaloid behaves like cevine (q.v.) giving a mixture of
bases and hydrocarbons from which the following have been isolated; 5-methyl-
2-ethylpyridine; 5-methyl-2-ethyl-3-hydroxypyridine; C2oH22 , m.p. 79°C;
C24H30, m.p. 100- 1°C; C2l H24 , m.p. 70-8 1°C; C2oH 16 , m.p. I 25-7°C and
C22H20 , m.p. I 54-5℃。
In large doses, the alkaloid produces vasodilatation and a fall in blood
pressure
Has antibacterial properties. Jervine demonstrates teratogenic properties. It is the starting material for C-nor-D-homosteroids. Jervine induces holoprosencephaly and blocks endogenous Sonic hedgehog signaling
Safety
| Symbol(GHS) |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H301-H360D |
| Precautionary statements | P201-P301+P310+P330 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | WG9700000 |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29349990 |
| Hazardous Substances Data | 469-59-0(Hazardous Substances Data) |
| Toxicity | LD50 i.v. in mice: 9.3 mg/kg (Krayer); LD50 s.c. in male mice: 29 mg/kg (Tanaka) |
