ProtoveratrineA , ≥98% , 143-57-7
CAS NO.：143-57-7
Empirical Formula: C41H63NO14
Molecular Weight: 793.94
MDL number: MFCD00135586
EINECS: 205-602-9
PRODUCT Properties
| Melting point: | 267-269°C |
| alpha | D25 -40.5° (pyridine); D25 -10.5° (chloroform) |
| Boiling point: | 747.91°C (rough estimate) |
| Density | 1.36±0.1 g/cm3 (20 ºC 760 Torr) |
| refractive index | 1.6220 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | powder |
| pka | 10.74±0.70(Predicted) |
| color | White |
Description and Uses
A further alkaloid isolated from Veratrum album, this base yields colourless crystals from EtOH. It is laevorotatory with [α]27D - 44.1° (pyridine) or - 12.1° (CHC13). Like the preceding base, it dissolves in H2S04 to give a blue colour. The complex with maleic acid has been prepared as colourless crystals, m.p. 241.5°C; [α]20D - 37.6°. On alkaline hydrolysis, the alkaloid furnishes protoverine, two moles of acetic acid, one mole of (-)-methylbutyric acid and one mole of (+)-2-hydroxy-2-methylbutyric acid.
Protoveratrine A is a pharmacological agent which displays neuroprotective effects in ischemic stroke.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H300+H310+H330 |
| Precautionary statements | P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310 |
| Hazard Codes | T+ |
| Risk Statements | 26/27/28 |
| Safety Statements | 22-36/37/39-45 |
| RIDADR | UN 1544 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | FL5750100 |
| HazardClass | 6.1(a) |
| PackingGroup | I |
| Toxicity | LD50 s.c. in male mice: 0.29 mg/kg (Tanaka) |
