LN-677433
Hh-Ag 1.3 , 98% , 364590-63-6
Synonym(s):
Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem
CAS NO.：364590-63-6
Empirical Formula: C28H28ClN3OS
Molecular Weight: 490.06
MDL number: MFCD14636155
Update time: 2023-04-23
PRODUCT Properties
| Boiling point: | 688.6±55.0 °C(Predicted) |
| Density | 1.30±0.1 g/cm3(Predicted) |
| pka | 10?+-.0.40(Predicted) |
| form | White to off-white solid. |
| Water Solubility | Soluble in water. |
| Sensitive | Light Sensitive & Hygroscopic |
Description and Uses
Smoothened Agonist, HCl (SAG), is a highly potent activator of Smo (smoothened). This chlorobenzothiophene compound is a hedgehog pathway agonist that interacts with the heptahelical domain of Smo. SAG is shown to act as an activator at low concentrations, but can inhibit Smo coupling at very high concentrations. The activating effects of SAG will counteract Cyclopamine or Cyclopamine-KAAD inhibition of Smo.
