Purmorphamine , ≥98% , 483367-10-8

Synonym(s):
2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine; 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-

CAS NO.：483367-10-8

Empirical Formula: C31H32N6O2

Molecular Weight: 520.62

MDL number: MFCD09037557

EINECS: 200-256-5

Pack Size	Price	Stock	Quantity
5MG	RMB676.00	In Stock
10MG	RMB963.20	In Stock
25MG	RMB1969.60	In Stock
100MG	RMB6959.20	In Stock
others			Enquire

Update time: 2022-07-08

PRODUCT Properties

Melting point:	210-212°C
Boiling point:	790.3±70.0 °C(Predicted)
Density	1.35±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: soluble5mg/mL, clear (warmed)
pka	5.44±0.40(Predicted)
form	powder
color	white to beige
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey	FYBHCRQFSFYWPY-UHFFFAOYSA-N

Description and Uses

Small molecules that promote osteoblast differentiation might be useful as therapeutic agents for bone diseases such as osteoporosis. Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts. The EC₅₀ value for differentiation of C3H10T1/2 cells based on alkaline phosphatase expression is 1 μM. Investigation into purmorphamine’s mechanism of action indicates that it directly binds to and activates the 7-transmembrane Smo receptor of the Hedgehog signaling pathway.

Purmorphamine has been used to study the consequences of upregulation of Hedgehog signalling pathway in Tupfel long fin strain Zebrafish.