Cyclopamine , ≥99% , 4449-51-8

Synonym(s):
11-Deoxyjervine;Cyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem

CAS NO.：4449-51-8

Empirical Formula: C27H41NO2

Molecular Weight: 411.62

MDL number: MFCD09878269

PRODUCT Properties

• Melting point: 236-238°C
• Boiling point: 531.29°C (rough estimate)
• Density: 1.0274 (rough estimate)
• refractive index: 1.6400 (estimate)
• storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• solubility: DMSO: soluble
• form: solid
• pka: 15.05±0.70(Predicted)
• color: White
• Stability: Store in Freezer at - 20°C

Description and Uses

Cyclopamine is a natural steroidal alkaloid that inhibits signaling through the hedgehog pathway at the level of the pathway activator Smoothened. By altering gene expression in this signaling sequence, cyclopamine induces defects in morphogenesis, first observed in chicks and sheep as cyclopia. As a readout of action, cyclopamine inhibits hedgehog-dependent expression of Pax7 with an IC₅₀ value of 24 nM. Although teratogenic during development, cyclopamine has potential applications in the treatment of cancer.

Cyclopamine antibacterial properties. Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and Patched.

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H301-H360D
• Precautionary statements: P202-P264-P270-P280-P301+P310-P405
• Hazard Codes: Xi
• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: GY0750000
• HS Code: 29349990