Cyclopamine , ≥99% , 4449-51-8
Synonym(s):
11-Deoxyjervine;Cyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem
Pack Size | Price | Stock | Quantity |
5MG | RMB639.20 | In Stock |
|
10MG | RMB878.40 | In Stock |
|
50MG | RMB2399.20 | In Stock |
|
others | Enquire |
PRODUCT Properties
Melting point: | 236-238°C |
Boiling point: | 531.29°C (rough estimate) |
Density | 1.0274 (rough estimate) |
refractive index | 1.6400 (estimate) |
storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
solubility | DMSO: soluble |
form | solid |
pka | 15.05±0.70(Predicted) |
color | White |
Stability: | Store in Freezer at - 20°C |
Description and Uses
Cyclopamine is a natural steroidal alkaloid that inhibits signaling through the hedgehog pathway at the level of the pathway activator Smoothened. By altering gene expression in this signaling sequence, cyclopamine induces defects in morphogenesis, first observed in chicks and sheep as cyclopia. As a readout of action, cyclopamine inhibits hedgehog-
Cyclopamine antibacterial properties. Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and Patched.
Safety
Symbol(GHS) | GHS06,GHS08 |
Signal word | Danger |
Hazard statements | H301-H360D |
Precautionary statements | P202-P264-P270-P280-P301+P310-P405 |
Hazard Codes | Xi |
Safety Statements | 22-24/25 |
WGK Germany | 3 |
RTECS | GY0750000 |
HS Code | 29349990 |
Hazardous Substances Data | 4449-51-8(Hazardous Substances Data) |