A7622858
Paliperidone , 2mMinDMSO , 144598-75-4
Synonym(s):
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one;9-Hydroxyrisperidone
CAS NO.：144598-75-4
Empirical Formula: C23H27FN4O3
Molecular Weight: 426.48
MDL number: MFCD00871802
EINECS: 620-493-1
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 158-160°C |
| Boiling point: | 612.3±65.0 °C(Predicted) |
| Density | 1.45±0.1 g/cm3(Predicted) |
| Flash point: | 9℃ |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble2mg/mL, clear (warmed) |
| pka | 13.00±0.60(Predicted) |
| form | powder |
| color | white to brown |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| InChI | InChI=1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3 |
| InChIKey | PMXMIIMHBWHSKN-UHFFFAOYSA-N |
| SMILES | C12C(O)CCCN1C(=O)C(CCN1CCC(C3C4=C(ON=3)C=C(F)C=C4)CC1)=C(C)N=2 |
| CAS DataBase Reference | 144598-75-4(CAS DataBase Reference) |
Description and Uses
Paliperidone, the C-9 hydroxylated active metabolite of the antipsychotic agent risperidone, is the newest atypical antipsychotic to join the market following the introductions of olanzapine (ZyprexaTM), risperidone (RisperdalTM), quetiapine(SeroquelTM), and ziprasidone (GeodonTM). Compared to its parent, paliperidone has improved PK properties and a reduced potential for drug interactions. In terms of receptor affinity, the two drugs are equipotent.
A metabolite of Risperidone, a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301+P310 |
| Hazard Codes | T,F |
| Risk Statements | 25-39/23/24/25-23/24/25-11 |
| Safety Statements | 45-36/37-16 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | UV1164720 |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29349990 |
| Hazardous Substances Data | 144598-75-4(Hazardous Substances Data) |
| Toxicity | rat,LD50,oral,65mg/kg (65mg/kg),Drug Development Research. Vol. 33, Pg. 399, 1994. |
