Paliperidone , 2mMinDMSO , 144598-75-4

Synonym(s):
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one;9-Hydroxyrisperidone

CAS NO.：144598-75-4

Empirical Formula: C23H27FN4O3

Molecular Weight: 426.48

MDL number: MFCD00871802

EINECS: 620-493-1

PRODUCT Properties

• Melting point: 158-160°C
• Boiling point: 612.3±65.0 °C(Predicted)
• Density: 1.45±0.1 g/cm3(Predicted)
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: DMSO: soluble2mg/mL, clear (warmed)
• pka: 13.00±0.60(Predicted)
• form: powder
• color: white to brown
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
• InChI: InChI=1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3
• InChIKey: PMXMIIMHBWHSKN-UHFFFAOYSA-N
• SMILES: C12C(O)CCCN1C(=O)C(CCN1CCC(C3C4=C(ON=3)C=C(F)C=C4)CC1)=C(C)N=2

Description and Uses

Paliperidone, the C-9 hydroxylated active metabolite of the antipsychotic agent risperidone, is the newest atypical antipsychotic to join the market following the introductions of olanzapine (ZyprexaTM), risperidone (RisperdalTM), quetiapine(SeroquelTM), and ziprasidone (GeodonTM). Compared to its parent, paliperidone has improved PK properties and a reduced potential for drug interactions. In terms of receptor affinity, the two drugs are equipotent.

A metabolite of Risperidone, a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P301+P310
• Hazard Codes: T,F
• Risk Statements: 25-39/23/24/25-23/24/25-11
• Safety Statements: 45-36/37-16
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: UV1164720
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 29349990
• Toxicity: rat,LD50,oral,65mg/kg (65mg/kg),Drug Development Research. Vol. 33, Pg. 399, 1994.