Iloperidone , ≥98% , 133454-47-4

Synonym(s):
1-[4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone;Iloperidone;Zomaril

CAS NO.：133454-47-4

Empirical Formula: C24H27FN2O4

Molecular Weight: 426.48

MDL number: MFCD00866688

EINECS: 603-745-5

PRODUCT Properties

• Melting point: 118-120°C
• Boiling point: 593.7±50.0 °C(Predicted)
• Density: 1.204±0.06 g/cm3(Predicted)
• Flash point: 9℃
• storage temp.: -20°C
• solubility: DMSO: soluble5mg/mL, clear
• form: powder
• pka: 8.43±0.20(Predicted)
• color: white to beige
• Merck: 14,4900

Description and Uses

Iloperidone is an atypical antipsychotic and adrenergic, dopamine, and serotonin (5-HT) receptor antagonist. It binds to several receptors, including the α₁-adrenergic receptor (α₁-AR), α₂-AR, and dopamine D₂ receptor (K_is = 0.31, 3, and 3.3 nM, respectively), as well as the 5-HT_1A, 5-HT_1D, 5-HT_2A, and 5-HT_2C receptors (K_is = 33, 15, 0.2, and 14 nM, respectively) in radioligand binding assays using human post-mortem brain tissue. Iloperidone also binds to human D₁, D₃, D₄, D₅, and rat 5-HT₂ receptors (K_is = 216, 7.1, 25, 319, and 3.1 nM, respectively, in CHO cells) and the histamine H₁ receptor (K_i = 12.3 nM in human post-mortem brain tissue). Iloperidone (1-3 mg/kg) prevents the reduction in prepulse inhibition induced by apomorphine , phencyclidine (PCP), and cirazoline in rats. It also increases the time rats spend in the open arms of the elevated plus maze and the number of social interactions when administered at a dose of 0.5 mg/kg. Formulations containing iloperidone have been used in the treatment of schizophrenia.

Combined dopamine (D2) and serotonin (5HT2) receptor antagonist. Antipsychotic.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301-H413
• Precautionary statements: P273-P301+P310+P330
• Hazard Codes: F,T
• Risk Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 16-36/37-45
• RIDADR: UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
• WGK Germany: 1
• RTECS: KM5777850
• HS Code: 29349990