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A5035512

Iloperidone , ≥98% , 133454-47-4

Synonym(s):
1-[4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone;Iloperidone;Zomaril

CAS NO.:133454-47-4

Empirical Formula: C24H27FN2O4

Molecular Weight: 426.48

MDL number: MFCD00866688

EINECS: 603-745-5

Pack Size Price Stock Quantity
50MG RMB239.20 In Stock
250MG RMB407.20 In Stock
1G RMB704.00 In Stock
5g RMB1742.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 118-120°C
Boiling point: 593.7±50.0 °C(Predicted)
Density  1.204±0.06 g/cm3(Predicted)
Flash point: 9℃
storage temp.  -20°C
solubility  DMSO: soluble5mg/mL, clear
form  powder
pka 8.43±0.20(Predicted)
color  white to beige
Merck  14,4900

Description and Uses

Iloperidone is an atypical antipsychotic and adrenergic, dopamine, and serotonin (5-HT) receptor antagonist. It binds to several receptors, including the α1-adrenergic receptor (α1-AR), α2-AR, and dopamine D2 receptor (Kis = 0.31, 3, and 3.3 nM, respectively), as well as the 5-HT1A, 5-HT1D, 5-HT2A, and 5-HT2C receptors (Kis = 33, 15, 0.2, and 14 nM, respectively) in radioligand binding assays using human post-mortem brain tissue. Iloperidone also binds to human D1, D3, D4, D5, and rat 5-HT2 receptors (Kis = 216, 7.1, 25, 319, and 3.1 nM, respectively, in CHO cells) and the histamine H1 receptor (Ki = 12.3 nM in human post-mortem brain tissue). Iloperidone (1-3 mg/kg) prevents the reduction in prepulse inhibition induced by apomorphine , phencyclidine (PCP), and cirazoline in rats. It also increases the time rats spend in the open arms of the elevated plus maze and the number of social interactions when administered at a dose of 0.5 mg/kg. Formulations containing iloperidone have been used in the treatment of schizophrenia.

Combined dopamine (D2) and serotonin (5HT2) receptor antagonist. Antipsychotic.

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301-H413
Precautionary statements  P273-P301+P310+P330
Hazard Codes  F,T
Risk Statements  11-23/24/25-39/23/24/25
Safety Statements  16-36/37-45
RIDADR  UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany  1
RTECS  KM5777850
HS Code  29349990
Hazardous Substances Data 133454-47-4(Hazardous Substances Data)

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