Home Categories Biochemical Engineering Silodosin
A7367712

Silodosin , ≥99% , 160970-54-7

CAS NO.:160970-54-7

Empirical Formula: C25H32F3N3O4

Molecular Weight: 495.53

MDL number:

EINECS: 814-909-2

Pack Size Price Stock Quantity
5MG RMB69.60 In Stock
25MG RMB197.60 In Stock
250mg RMB409.60 In Stock
100MG RMB523.20 In Stock
1g RMB1140.00 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: >104°C (dec.)
alpha  D25 -14.0° (c = 1.01 in methanol)
Boiling point: 601.4±55.0 °C(Predicted)
Density  1.249±0.06 g/cm3(Predicted)
storage temp.  under inert gas (nitrogen or Argon) at 2–8 °C
solubility  Aqueous Base (Slightly, Heated Sonicated), DMSO (Slightly, Sonicated), Methanol
pka 14.85±0.10(Predicted)
form  Solid
color  White to Off-White
InChIKey PNCPYILNMDWPEY-QGZVFWFLSA-N
SMILES N1(CCCO)C2=C(C=C(C[C@H](NCCOC3=CC=CC=C3OCC(F)(F)F)C)C=C2C(N)=O)CC1
CAS DataBase Reference 160970-54-7(CAS DataBase Reference)

Description and Uses

Silodosin, an a1A adrenoceptor (a1A-AR) antagonist selective for prostatic receptors, was launched as an oral treatment for dysuria associated with benign prostatic hypertrophy (BPH). The regulation of smooth muscle tone in the bladder neck and prostate is thought to be primarily mediated by a1A-AR. Blockade of these receptors can cause smooth muscle relaxation in these areas, resulting in improved symptoms and urinary flow rates. Conversely, a1B-AR are largely located on vascular smooth muscle, and antagonism of these receptors can cause tissue relaxation and potentially decrease cardiac compensation mechanisms involved in regulating blood pressure.

Silodosin(Rapaflo) is an α1-adrenoceptor antagonist with high uroselectivity. It causes practically no orthostatic hypotension (in contrast to other α1 blockers). Since Silodosin is a highly selective inhibitor of the α1A adrenergic receptor, it causes pr

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
HS Code  29339900

RELATED PRODUCTS