Silodosin , ≥99% , 160970-54-7

CAS NO.：160970-54-7

Empirical Formula: C25H32F3N3O4

Molecular Weight: 495.53

MDL number:

EINECS: 814-909-2

PRODUCT Properties

• Melting point: >104°C (dec.)
• alpha: D25 -14.0° (c = 1.01 in methanol)
• Boiling point: 601.4±55.0 °C(Predicted)
• Density: 1.249±0.06 g/cm3(Predicted)
• storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• solubility: Aqueous Base (Slightly, Heated Sonicated), DMSO (Slightly, Sonicated), Methanol
• pka: 14.85±0.10(Predicted)
• form: Solid
• color: White to Off-White
• InChIKey: PNCPYILNMDWPEY-QGZVFWFLSA-N
• SMILES: N1(CCCO)C2=C(C=C(C[C@H](NCCOC3=CC=CC=C3OCC(F)(F)F)C)C=C2C(N)=O)CC1

Description and Uses

Silodosin, an a1A adrenoceptor (a1A-AR) antagonist selective for prostatic receptors, was launched as an oral treatment for dysuria associated with benign prostatic hypertrophy (BPH). The regulation of smooth muscle tone in the bladder neck and prostate is thought to be primarily mediated by a1A-AR. Blockade of these receptors can cause smooth muscle relaxation in these areas, resulting in improved symptoms and urinary flow rates. Conversely, a1B-AR are largely located on vascular smooth muscle, and antagonism of these receptors can cause tissue relaxation and potentially decrease cardiac compensation mechanisms involved in regulating blood pressure.

Silodosin(Rapaflo) is an α1-adrenoceptor antagonist with high uroselectivity. It causes practically no orthostatic hypotension (in contrast to other α1 blockers). Since Silodosin is a highly selective inhibitor of the α1A adrenergic receptor, it causes pr

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
• HS Code: 29339900