Vilazodone , ≥98% , 163521-12-8

CAS NO.：163521-12-8

Empirical Formula: C26H27N5O2

Molecular Weight: 441.52

MDL number: MFCD09838919

EINECS: 1308068-626-2

PRODUCT Properties

• Melting point: 203-205°C
• Boiling point: 745.1±60.0 °C(Predicted)
• Density: 1.34±0.1 g/cm3(Predicted)
• storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• solubility: DMSO (Slightly)), Methanol (Slightly)
• pka: 15.98±0.30(Predicted)
• form: Solid
• color: Pale Yellow to Beige
• Stability: Very Hygroscopic
• InChIKey: SGEGOXDYSFKCPT-UHFFFAOYSA-N
• SMILES: O1C2=CC=C(N3CCN(CCCCC4C5=C(NC=4)C=CC(C#N)=C5)CC3)C=C2C=C1C(N)=O

Description and Uses

In January 2011, the U.S. FDA approved vilazodone for the treatment of major depressive disorder (MDD). Vilazodone is a novel antidepressant agent that combines potent serotonin reuptake inhibition (IC₅₀=0.2 nM) with high affinity for 5-HT1A receptors (IC₅₀=0.5 nM)and partial 5-HT1A receptor agonist functional activity. Vilazodone has good selectivity over other monoamine receptors and is efficacious in preclinical models of depression in rats and mice. Vilazodone is an indolylbutylpiperazine derivative that has been prepared by coupling of an indolylbutyl chloride or tosylate with 5-(piperazin-1-yl)benzofuran-2- carboxamide or the corresponding ester. The cyanoindole portion of vilazodone is important for conferring high affinity for both the serotonin transporter and the 5-HT1A receptor. Para-substitution on the phenyl group attached to the piperidine moiety reduces affinity for dopamine receptors, while the carboxamide group provides improved pharmacokinetic properties.

Labelled analogue of Vilazodone