Voriconazole , ≥98% , 137234-62-9

Synonym(s):
2R,3S-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol;UK-109496;Voriconazole

CAS NO.：137234-62-9

Empirical Formula: C16H14F3N5O

Molecular Weight: 349.31

MDL number: MFCD00905717

EINECS: 629-701-5

PRODUCT Properties

• Melting point: 127-130°C
• alpha: D25 -62° (c = 1 in methanol)
• Boiling point: 508.6±60.0 °C(Predicted)
• Density: 1.42±0.1 g/cm3(Predicted)
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: DMSO: >20mg/mL
• pka: 11.54±0.29(Predicted)
• form: white powder
• color: White to Almost white
• Merck: 14,10033
• InChI: InChI=1/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/s3
• InChIKey: BCEHBSKCWLPMDN-MGPLVRAMSA-N
• SMILES: [C@@](C1C=CC(F)=CC=1F)(O)(CN1N=CN=C1)[C@H](C1=NC=NC=C1F)C |&1:0,16,r|

Description and Uses

Voriconazole is a broad-spectrum triazole antifungal ,it is primarily used for the treatment of progressive, possibly life-threatening infections in immune deficiency patients. Indications include: immunosuppressed patients with severe fungal infections, acute invasive aspergillosis (the most common pathogen is Aspergillus fumigatus, followed by A. flavus, Aspergillus niger and Aspergillus soil), severe invasive infections caused by fluconazole-resistant Candida (including C. krusei) severe infection caused by Foot actinomycetes bacteria genus and Fusarium bacteria genus . Moderate to severe renal insufficiency is administered intravenously paying caution.

Voriconazole is an antifungal (systemic) that belong to an ergosterol biosynthesis inhibitor. It is used to treat serious fungal or yeast infections, such as aspergillosis (fungal infection in the lungs), candidemia (fungal infection in the blood), esophageal candidiasis (candida esophagitis), or other fungal infections (infections in the skin, stomach, kidney, bladder, or wounds).

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H301-H341-H351-H361-H371-H372-H373-H412
• Precautionary statements: P201-P202-P260-P264-P273-P301+P310
• Hazard Codes: Xn,T,F
• Risk Statements: 22-36/38-52/53-48/22-40-25-61-39/23/24/25-23/24/25-11
• Safety Statements: 26-36-45-36/37-22-53-16
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 3
• RTECS: UV9145000
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 29335990