Candesartan , ≥99% , 139481-59-7

CAS NO.：139481-59-7

Empirical Formula: C24H20N6O3

Molecular Weight: 440.45

MDL number: MFCD00864463

EINECS: 604-138-8

PRODUCT Properties

• Melting point: 183-185°C
• Boiling point: 754.8±70.0 °C(Predicted)
• Density: 1.41±0.1 g/cm3(Predicted)
• RTECS: DD6671000
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• solubility: Soluble in DMSO (up to 40 mg/ml)
• form: solid
• pka: 2.06±0.10(Predicted)
• color: White
• Water Solubility: Soluble in ethyl acetate, methanol, water (<1 mg/ml at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Description and Uses

Candesartan (CAS 139481-59-7) is an angiotensin II receptor I (AT1) antagonist, IC50s=1.12 and 2.86 nM for bovine adrenal cortex and rabbit aorta respectively.1?Selectively inhibits angiotensin II-induced contraction of rabbit aortic strips with no effect on contraction induced by other agents such as norepinephrine, KCl, serotonin, PGF2αor endothelin. Prevents astrocyte and microglial activation and neuroinflammation and improves hippocampal neurogenesis.2?Attenuates angiogenesis in hepatocellular carcinoma.3?Clinically useful antihypertensive agent. Ameliorates brain inflammation associated with Alzheimer’s disease.4?Active?in vivo?and orally active.

Candesartan is a selective AT1 (angiotensin II receptor 1) antagonist. Antagonism of angiotensin receptors inhibits vasoconstriction and the production of aldosterone, leading to a decrease in water and sodium concentration in blood plasma. Exhibits antihypertensive effects in animal models. Used in treatment of congestive heart failure, as antihypertensive. Candesartan does not affect cell viability or proliferation but increases the expression of VEGF and interleukin-8 in the cultured medium of KU-19-19 cells. Candesartan (0.1 nM) could reduce the maximal contractile response to angiostensin II by approximately 50%.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H312-H315-H319-H332-H335
• Precautionary statements: P261-P280-P304+P340-P305+P351+P338-P405-P501a
• Hazard Codes: Xn
• Risk Statements: 20/21/22-36/37/38
• Safety Statements: 26-36-60-36/37-9
• HS Code: 29419000