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A2471912

Candesartan , ≥99% , 139481-59-7

CAS NO.:139481-59-7

Empirical Formula: C24H20N6O3

Molecular Weight: 440.45

MDL number: MFCD00864463

EINECS: 604-138-8

Pack Size Price Stock Quantity
10MG RMB119.20 In Stock
1G RMB127.20 In Stock
100MG RMB220.80 In Stock
5G RMB319.20 In Stock
25g RMB959.20 In Stock
100g RMB3167.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 183-185°C
Boiling point: 754.8±70.0 °C(Predicted)
Density  1.41±0.1 g/cm3(Predicted)
RTECS  DD6671000
storage temp.  Inert atmosphere,Store in freezer, under -20°C
solubility  Soluble in DMSO (up to 40 mg/ml)
form  solid
pka 2.06±0.10(Predicted)
color  White
Water Solubility  Soluble in ethyl acetate, methanol, water (<1 mg/ml at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
CAS DataBase Reference 139481-59-7(CAS DataBase Reference)

Description and Uses

Candesartan (CAS 139481-59-7) is an angiotensin II receptor I (AT1) antagonist, IC50s=1.12 and 2.86 nM for bovine adrenal cortex and rabbit aorta respectively.1?Selectively inhibits angiotensin II-induced contraction of rabbit aortic strips with no effect on contraction induced by other agents such as norepinephrine, KCl, serotonin, PGF2αor endothelin. Prevents astrocyte and microglial activation and neuroinflammation and improves hippocampal neurogenesis.2?Attenuates angiogenesis in hepatocellular carcinoma.3?Clinically useful antihypertensive agent. Ameliorates brain inflammation associated with Alzheimer’s disease.4?Active?in vivo?and orally active.

Candesartan is a selective AT1 (angiotensin II receptor 1) antagonist. Antagonism of angiotensin receptors inhibits vasoconstriction and the production of aldosterone, leading to a decrease in water and sodium concentration in blood plasma. Exhibits antihypertensive effects in animal models. Used in treatment of congestive heart failure, as antihypertensive. Candesartan does not affect cell viability or proliferation but increases the expression of VEGF and interleukin-8 in the cultured medium of KU-19-19 cells. Candesartan (0.1 nM) could reduce the maximal contractile response to angiostensin II by approximately 50%.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H312-H315-H319-H332-H335
Precautionary statements  P261-P280-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36-60-36/37-9
HS Code  29419000
Hazardous Substances Data 139481-59-7(Hazardous Substances Data)

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