Valsartan , ≥98%(HPLC) , 137862-53-4

Synonym(s):
N-(1-Oxopentyl)-N-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-L-valine;Valsartan

CAS NO.：137862-53-4

Empirical Formula: C24H29N5O3

Molecular Weight: 435.52

MDL number: MFCD00865840

EINECS: 1592732-453-0

PRODUCT Properties

• Melting point: 116-117°C
• Boiling point: 684.9±65.0 °C(Predicted)
• Density: 1.212±0.06 g/cm3(Predicted)
• vapor pressure: 0-0Pa at 20-25℃
• storage temp.: 2-8°C
• solubility: DMSO: ≥20mg/mL
• form: powder
• pka: 3.56±0.10(Predicted)
• color: white to tan
• optical activity: [α]/D -55 to -70°, c = 1 in methanol
• Water Solubility: 84.99mg/L(25 ºC)
• Merck: 14,9916
• BCS Class: 2
• Stability: Hygroscopic
• InChIKey: ACWBQPMHZXGDFX-QFIPXVFZSA-N
• LogP: 1.2-2.8 at 25℃ and pH2.5-7
• Surface tension: 59.6-68.1mN/m at 10-100mg/L and 20℃
• Dissociation constant: 3.76-4.38 at 25℃
• CAS DataBase Reference: 137862-53-4(CAS DataBase Reference)
• EPA Substance Registry System: L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (137862-53-4)

Description and Uses

Diovan(Valsartan) was launched in Germany and the UK as an angiotensin Ⅱ antagonist for use as an antihypertensive agent. Biphenylbromomethyl nitrite serves as the starting material for a three step synthesis of the compound, in which the (S)- enantiomer is more active than the (R)-enantiomer. Valsartan is a nonpeptide drug which is a highly specific antagonist of the AT₁ receptor and is potent and orally active. This receptor is responsible for angiotensin Ⅱ cardiovascular effects (aldosterone and catecholamine secretion, vascular constriction, positive inotropic response and renal effects). Unlike losartan, it is not a prodrug and a single daily dose is comparible in activity to the ACE drug enalapril. It also did not exhibit the coughing side effect observed with ACE inhibitors. Diovan(Valsartan) is slowly metabolized (long lasting) with its main metabolite being significantly less active. There was no evidence of rebound hypertension when drug treatment was terminated and was as effective as the dihydropyridine Ca antagonist anlodipine.

Valsartan is used as a first-line drug for the treatment of uncomplicated hypertension, isolated systolic hypertension, and left ventricular hypertrophy. Valsartan is a clinically widely used antihypertensive agent with the advantages of low side effects and good tolerability, and can also be used for the treatment of hypertension in patients with diabetes and renal disease.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H336-H361d
• Precautionary statements: P201-P308+P313
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• RTECS: YV9455000
• HS Code: 29339900
• Hazardous Substances Data: 137862-53-4(Hazardous Substances Data)