Telmisartan , ≥98% , 144701-48-4

Synonym(s):
4′[(1,4′-Dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl][1,1′-biphenyl]-2-carboxylic acid;BIBR 277;Telmisartan

CAS NO.：144701-48-4

Empirical Formula: C33H30N4O2

Molecular Weight: 514.62

MDL number: MFCD00929085

EINECS: 620-494-7

PRODUCT Properties

• Melting point: 261-263°C
• Boiling point: 771.9±70.0 °C(Predicted)
• Density: 1.16
• RTECS: DV2037500
• storage temp.: 2-8°C
• solubility: DMSO: >5 mg/mL at 60 °C
• pka: 3.86±0.36(Predicted)
• form: solid
• color: white
• Water Solubility: insoluble
• Merck: 14,9129
• BCS Class: 2
• Stability: Hygroscopic
• InChIKey: RMMXLENWKUUMAY-UHFFFAOYSA-N
• SMILES: C1(C2=CC=C(CN3C(CCC)=NC4=C(C)C=C(C5N(C)C6=CC=CC=C6N=5)C=C43)C=C2)=CC=CC=C1C(O)=O

Description and Uses

Telmisartan is an angiotensin receptor blocker (ARB), It is used in the treatment of hypertension also effective in cardiovascular risk reduction.Telmisartan blocks the action of angiotensin II (Ang II), the primary effector molecule of the renin-angiotensin-aldosterone system (RAAS). It is the sixth of this class of 《sartans》 to be marketed after the lead compound Losartan. Its long lasting effect (24h half-life) could be the main difference with other angiotensin II antagonists. Unlike several other agents in this category, its activity does not depend upon transformation into an active metabolite, the 1-O-acylglucuronide being the principal metabolite found in humans. Telmisartan is a potent competitive antagonist of AT1 receptors that mediate most of the important effects of angiotensin II while lacking affinity for the AT2 subtypes or other receptors involved in cardiovascular regulation.

Telmisartan, an angiotensin II receptor antagonist, is an effective medication for the treatment of hypertension. It can be used alone or in combination with other antihypertensive drugs. Additionally, it is beneficial in the treatment of diabetic nephropathy in hypertensive individuals with type 2 diabetes mellitus. Telmisartan is also used to address congestive heart issues.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 22-24/25-36-26
• WGK Germany: 2
• HS Code: 2933995300