Candesartan Cilexetil , ≥98% , 145040-37-5

Synonym(s):
2-ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-Benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester;Candesartan cilexetil;TCV 116;TCY 116

CAS NO.：145040-37-5

Empirical Formula: C33H34N6O6

Molecular Weight: 610.66

MDL number: MFCD00871371

EINECS: 627-030-2

PRODUCT Properties

• Melting point: 168-170?C
• Boiling point: 843.3±75.0 °C(Predicted)
• Density: 1.37±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: ≥15mg/mL
• pka: pKa 3.55 (H2O t=25.0 I=0.025) (Uncertain);5.91(H2O t=25.0 I=0.025) (Uncertain)
• form: powder
• color: white to beige
• λmax: 304nm(EtOH)(lit.)
• Merck: 14,1739
• BCS Class: 2
• InChIKey: GHOSNRCGJFBJIB-UHFFFAOYSA-N
• SMILES: C1(OCC)N(CC2=CC=C(C3=CC=CC=C3C3=NNN=N3)C=C2)C2=C(C(OC(OC(OC3CCCCC3)=O)C)=O)C=CC=C2N=1

Description and Uses

Candesartan cilexetil is a prodrug form of the angiotensin II type 1 receptor (AT1) antagonist candesartan . Atacand was launched in Australia, Belgium, Canada, Denmark, Finland, the Netherlands, Norway, Sweden, S. Africa and the US as an antihypertensive agent. Pharmacological studies have indicated Atacand is about 10-fold more potent than Losartan and has a long elimination half-life. Like losartan, Atacand is converted to its active form during GI absorption (via ester hydrolysis). It is a potent antagonist of angiotensin II type 1 receptors. This occurs through tight binding and slow dissociation, and is more potent than ACE inhibitors. It is well tolerated (can be taken by elderly and those with type II diabetes) and has no gender effects.

N,N-Desmethoxyethyl Candesartan Cilexetil is an impurity of Candesartan Cilexetil(C175580); An antihypertensive used in the treatment of congestive heart failures.

Safety

• Symbol(GHS): GHS08,GHS09
• Signal word: Warning
• Hazard statements: H361-H400
• Precautionary statements: P280
• Hazard Codes: Xn,N,T
• Risk Statements: 20/21/22-36/37/38-50-48/20-61
• Safety Statements: 26-36-61-45-53
• WGK Germany: 3
• RTECS: DD6672500
• HS Code: 29339953
• Toxicity: dog,LD50,oral,> 2gm/kg (2000mg/kg),Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 406, 2000.