Rofecoxib , ≥98% , 162011-90-7
Synonym(s):
4-[4-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
CAS NO.：162011-90-7
Empirical Formula: C17H14O4S
Molecular Weight: 314.36
MDL number: MFCD00935806
EINECS: 803-260-0
| Pack Size | Price | Stock | Quantity |
| 50MG | RMB175.20 | In Stock |
|
| 250MG | RMB623.20 | In Stock |
|
| 1g | RMB1960.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 207°C |
| Boiling point: | 577.6±50.0 °C(Predicted) |
| Density | 1.333±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| form | powder |
| color | white to beige |
| Water Solubility | 9mg/L(25 ºC) |
| Merck | 14,8248 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| CAS DataBase Reference | 162011-90-7(CAS DataBase Reference) |
Description and Uses
Rofecoxib ts a non-steroidal anti-inflammatory drug (NSAID) launched in Mexico, its first market, for the management of acute pain and the treatment of osteoarthritis (OA) and primary dysmenorrhea. Rofecoxib can be obtained by several different ways; one example is by arylation of a 4-bromofuranone with a phenylboronic acid under Suzuki conditions. Rofecoxib is a highly selective inhibitor of COX-2, the inducible isoform of cyclooxygenase and therefore exhibits a potent antiinflammatory activity without concomitant gastric or renal toxicities linked to the non-specific COX-1/2 inhibitors. In several clinical studies in patients with knee or hip osteoarthritis, Rofecoxib was evaluated at 12.5-50 mg doses once daily: it demonstrated efficacy for all primary and secondary endpoints at doses considerably weaker than those for classical non-specific NSAIDs, with good tolerance and less adverse effects. Selective COX-2 inhibitors potentially have a large spectrum of activity including new indications such as Alzheimer's disease, colorectal cancer, irritable bowel disease or urinary incontinence.
Labeled Rizatriptan, intended for use as an internal standard for the quantification of Rizatriptan by GC- or LC-mass spectrometry.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P501-P270-P264-P301+P312+P330 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 3 |
| RTECS | LU5135000 |
| HS Code | 2932.20.3000 |
| Hazardous Substances Data | 162011-90-7(Hazardous Substances Data) |
