racTamsulosinHydrochloride

Synonym(s):
(−)-(R)-5-[2-[[2-(o-ethoxy phenoxy)ethyl]amino]propyl]-2-methoxy benzene sulfonamide, monohydrochloride;5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride;TAM;Tamsulosin hydrochloride

CAS NO.：

Empirical Formula: C20H29ClN2O5S

Molecular Weight: 444.97

MDL number: MFCD00922997

EINECS: 629-756-5

PRODUCT Properties

• Melting point: 228-230°C
• alpha: D24 -4.0° (c = 0.35 in methanol)
• RTECS: DB2430000
• storage temp.: 2-8°C
• solubility: DMSO: >10mg/mL
• form: white powder
• color: White to Off-White
• Merck: 14,9049
• InChIKey: ZZIZZTHXZRDOFM-XFULWGLBSA-N
• CAS DataBase Reference: 106463-17-6(CAS DataBase Reference)

Description and Uses

Tamsulosin is a potent antagonist of α₁-adrenergic receptors (α₁-ARs; K_i = 0.229 nM in a radioligand binding assay). It is 3,800-fold selective for α₁-ARs over α₂-ARs (K_i = 871 nM). Tamsulosin antagonizes norepinephrine-induced contraction of isolated rabbit aorta (pA₂ = 10.11) but has no effect on contraction stimulated by histamine, serotonin , angiotensin II , or prostaglandin F_2α . In vivo, tamsulosin reverses the pressor effect of phenylephrine (Item Nos. 17205 | 18619) in pithed rats. It reversibly reduces fertility in male rats when administered at a dose of 0.15 mg/kg. Tamsulosin (1-100 μg/kg) also reduces prostatic pressure in a dose-dependent manner with minimal hypotensive effects in anesthetized dogs. Formulations containing tamsulosin have been used for the treatment of benign prostatic hyperplasia.

An α1-adrenoceptor antagonist

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P501
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HS Code: 29350090