Home Categories API Tamsulosin hydrochloride
A7647312

Tamsulosin hydrochloride , 98% , 106463-17-6

Synonym(s):
(−)-(R)-5-[2-[[2-(o-ethoxy phenoxy)ethyl]amino]propyl]-2-methoxy benzene sulfonamide, monohydrochloride;5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride;TAM;Tamsulosin hydrochloride

CAS NO.:106463-17-6

Empirical Formula: C20H29ClN2O5S

Molecular Weight: 444.97

MDL number: MFCD00922997

EINECS: 629-756-5

Pack Size Price Stock Quantity
5MG RMB87.20 In Stock
100MG RMB492.00 In Stock
500MG RMB1210.40 In Stock
1g RMB2191.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 228-230°C
alpha  D24 -4.0° (c = 0.35 in methanol)
RTECS  DB2430000
storage temp.  2-8°C
solubility  DMSO: >10mg/mL
form  white powder
color  White to Off-White
Merck  14,9049
InChIKey ZZIZZTHXZRDOFM-XFULWGLBSA-N

Description and Uses

Tamsulosin is a potent antagonist of α1-adrenergic receptors (α1-ARs; Ki = 0.229 nM in a radioligand binding assay). It is 3,800-fold selective for α1-ARs over α2-ARs (Ki = 871 nM). Tamsulosin antagonizes norepinephrine-induced contraction of isolated rabbit aorta (pA2 = 10.11) but has no effect on contraction stimulated by histamine, serotonin , angiotensin II , or prostaglandin F . In vivo, tamsulosin reverses the pressor effect of phenylephrine (Item Nos. 17205 | 18619) in pithed rats. It reversibly reduces fertility in male rats when administered at a dose of 0.15 mg/kg. Tamsulosin (1-100 μg/kg) also reduces prostatic pressure in a dose-dependent manner with minimal hypotensive effects in anesthetized dogs. Formulations containing tamsulosin have been used for the treatment of benign prostatic hyperplasia.

An α1-adrenoceptor antagonist

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26
WGK Germany  3
HS Code  29350090

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