Nimesulide , >98.0%(HPLC) , 51803-78-2

Synonym(s):
N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide;Nimesulide

CAS NO.：51803-78-2

Empirical Formula: C13H12N2O5S

Molecular Weight: 308.31

MDL number: MFCD00079470

EINECS: 257-431-4

PRODUCT Properties

• Melting point: 140-146°C
• Boiling point: 442.0±55.0 °C(Predicted)
• Density: 1.451±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: Practically insoluble in water, freely soluble in acetone, slightly soluble in anhydrous ethanol.
• pka: pKa 6.56± 0.03(H2O,t =25,I=0.02)(Approximate)
• form: Solid
• color: Light orange to Yellow to Green
• Water Solubility: Soluble in water (<50 &#181;g/ml), 1:10 DMSO:PBS (pH 7.2) (<200 &#181;g/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH.
• λmax: 391nm(H2O)(lit.)
• Merck: 14,6548
• Stability: Stable. Incompatible with strong oxidizing agents.
• InChIKey: HYWYRSMBCFDLJT-UHFFFAOYSA-N

Description and Uses

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC₅₀s = 1.27 and 0.03 μM for the human and ovine enzymes, respectively). It is selective for COX-2 over COX-1 (IC₅₀s = 70 and 22 μM for the human and ovine enzymes, respectively). Nimesulide also inhibits sodium-dependent neutral amino acid transporter (B⁰AT1) with an IC₅₀ value of 23 μM for the rat kidney transporter. It inhibits infection-induced increases in brain prostaglandin E₂ (PGE₂; ) levels, as well as reduces pyresis (ED₅₀ = 0.3 mg/kg), in yeast-infected rats. Nimesulide (2.9 mg/kg) inhibits formalin-induced hindpaw thermal hyperalgesia in rats.

For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P301+P310+P330
• Hazard Codes: Xn,Xi
• Risk Statements: 22-36/37/38
• Safety Statements: 36-26
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: PB0970000
• HS Code: 2935.90.9500
• HazardClass: 6.1
• PackingGroup: III
• Toxicity: LD50 orally in rats: 324 mg/kg (Swingle, Moore)