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A6346112

Nimesulide , >98.0%(HPLC) , 51803-78-2

Synonym(s):
N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide;Nimesulide

CAS NO.:51803-78-2

Empirical Formula: C13H12N2O5S

Molecular Weight: 308.31

MDL number: MFCD00079470

EINECS: 257-431-4

Pack Size Price Stock Quantity
1G RMB67.20 In Stock
5G RMB150.40 In Stock
25G RMB530.40 In Stock
100g RMB1627.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 140-146°C
Boiling point: 442.0±55.0 °C(Predicted)
Density  1.451±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  Practically insoluble in water, freely soluble in acetone, slightly soluble in anhydrous ethanol.
form  Solid
pka pKa 6.56± 0.03(H2O,t =25,I=0.02)(Approximate)
color  Light orange to Yellow to Green
Water Solubility  Soluble in water (<50 &#181;g/ml), 1:10 DMSO:PBS (pH 7.2) (<200 &#181;g/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH.
λmax 391nm(H2O)(lit.)
Merck  14,6548
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey HYWYRSMBCFDLJT-UHFFFAOYSA-N
CAS DataBase Reference 51803-78-2(CAS DataBase Reference)
EPA Substance Registry System Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)- (51803-78-2)

Description and Uses

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC50s = 1.27 and 0.03 μM for the human and ovine enzymes, respectively). It is selective for COX-2 over COX-1 (IC50s = 70 and 22 μM for the human and ovine enzymes, respectively). Nimesulide also inhibits sodium-dependent neutral amino acid transporter (B0AT1) with an IC50 value of 23 μM for the rat kidney transporter. It inhibits infection-induced increases in brain prostaglandin E2 (PGE2; ) levels, as well as reduces pyresis (ED50 = 0.3 mg/kg), in yeast-infected rats. Nimesulide (2.9 mg/kg) inhibits formalin-induced hindpaw thermal hyperalgesia in rats.

For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310+P330
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  36-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  PB0970000
HS Code  2935.90.9500
HazardClass  6.1
PackingGroup  III
Toxicity LD50 orally in rats: 324 mg/kg (Swingle, Moore)

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