Nimesulide , >98.0%(HPLC) , 51803-78-2
Synonym(s):
N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide;Nimesulide
CAS NO.:51803-78-2
Empirical Formula: C13H12N2O5S
Molecular Weight: 308.31
MDL number: MFCD00079470
EINECS: 257-431-4
Pack Size | Price | Stock | Quantity |
1G | RMB67.20 | In Stock |
|
5G | RMB150.40 | In Stock |
|
25G | RMB530.40 | In Stock |
|
100g | RMB1627.20 | In Stock |
|
others | Enquire |
PRODUCT Properties
Melting point: | 140-146°C |
Boiling point: | 442.0±55.0 °C(Predicted) |
Density | 1.451±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | Practically insoluble in water, freely soluble in acetone, slightly soluble in anhydrous ethanol. |
form | Solid |
pka | pKa 6.56± 0.03(H2O,t =25,I=0.02)(Approximate) |
color | Light orange to Yellow to Green |
Water Solubility | Soluble in water (<50 µg/ml), 1:10 DMSO:PBS (pH 7.2) (<200 µg/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH. |
λmax | 391nm(H2O)(lit.) |
Merck | 14,6548 |
Stability: | Stable. Incompatible with strong oxidizing agents. |
InChIKey | HYWYRSMBCFDLJT-UHFFFAOYSA-N |
CAS DataBase Reference | 51803-78-2(CAS DataBase Reference) |
EPA Substance Registry System | Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)- (51803-78-2) |
Description and Uses
Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC50s = 1.27 and 0.03 μM for the human and ovine enzymes, respectively). It is selective for COX-2 over COX-1 (IC50s = 70 and 22 μM for the human and ovine enzymes, respectively). Nimesulide also inhibits sodium-dependent neutral amino acid transporter (B0AT1) with an IC50 value of 23 μM for the rat kidney transporter. It inhibits infection-induced increases in brain prostaglandin E2 (PGE2; ) levels, as well as reduces pyresis (ED50 = 0.3 mg/kg), in yeast-infected rats. Nimesulide (2.9 mg/kg) inhibits formalin-induced hindpaw thermal hyperalgesia in rats.
For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.
Safety
Symbol(GHS) | GHS06 |
Signal word | Danger |
Hazard statements | H301 |
Precautionary statements | P301+P310+P330 |
Hazard Codes | Xn,Xi |
Risk Statements | 22-36/37/38 |
Safety Statements | 36-26 |
RIDADR | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | PB0970000 |
HS Code | 2935.90.9500 |
HazardClass | 6.1 |
PackingGroup | III |
Toxicity | LD50 orally in rats: 324 mg/kg (Swingle, Moore) |