Home Categories Biochemical Engineering Blasticidin-S-HCl
A7081158

Blasticidin-S-HCl , 10mMinWater , 3513-03-9

Synonym(s):
Blasticidin S, Hydrochloride, Streptomyces griseochromogenes - CAS 589205 - Calbiochem;Blasticidin S, Hydrochloride, Streptomyces sp., Sterile-Filtered Aqueous Solution, Cell Culture-Tested - CAS 589205 - Calbiochem

CAS NO.:3513-03-9

Empirical Formula: C17H27ClN8O5

Molecular Weight: 458.9

MDL number: MFCD02091640

Pack Size Price Stock Quantity
1ml RMB559.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 224-225 °C (decomp)
storage temp.  −20°C
solubility  Soluble in Water (greater than 25 mg/ml)
form  Liquid
color  White
Water Solubility  Soluble in water. Insoluble in organic solvents.
Stability: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.

Description and Uses

Blasticidin S HCl (3513-03-9) is a peptidyl nucleoside antibiotic inhibiting protein synthesis in bacteria and eukaryotes.1?Inhibits translation by trapping deformed tRNA on the ribosome.1?The ABC-type transporter NppA1A2BCD is required for uptake of blasticidin S and other peptidyl nucleoside antibiotics in?Pseudomonas aeruginosa?PA14.2?Selection agent for bis, bsr and bsd transformed cells.3,4

Blasticidin S hydrochloride is a salt of blasticidin S, an amphoteric nucleoside produced by several species of Streptomyces, first reported in the late 1950s. Blasticidin S hydrochloride was originally isolated fby acetone precipitation. For historical reasons only the salt has been routinely available to researchers. Both the salt and free base are freely water soluble. Blasticidin S is an antifungal agent with particularly potent activity against the rice pathogen, Piricularia oryzae, for which it was used commercially for some time in Japan. Blasticidin S inhibits protein synthesis and is active against bacteria, tumour cell lines and nematodes. More recently, blasticidin S has been used as a marker for strain manipulations.

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300
Precautionary statements  P264-P270-P301+P310-P405-P501
Hazard Codes  T+
Risk Statements  28
Safety Statements  28-36/37-45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
1-10
HazardClass  6.1
HS Code  29349990

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